Trans-synaptic interactions of ionotropic glutamate receptors.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
06
2020
revised:
01
08
2020
accepted:
01
09
2020
pubmed:
2
11
2020
medline:
26
5
2021
entrez:
1
11
2020
Statut:
ppublish
Résumé
Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic interactions are primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review the expanding extracellular and trans-synaptic proteome of iGluRs. We discuss the role of these molecular networks in specifying the formation of excitatory and inhibitory circuits and in the input-specific recruitment of iGluRs at synapses in various cell types and brain regions. We also shed light on human-specific mutations affecting iGluR-mediated trans-synaptic interactions that may provide unique features to the human brain and contribute to its susceptibility to neurodevelopmental disorders. Together, these data support a view in which iGluR function goes far beyond fast excitatory synaptic transmission by shaping the wiring and the functional properties of neural circuits.
Identifiants
pubmed: 33130410
pii: S0959-4388(20)30126-4
doi: 10.1016/j.conb.2020.09.001
pii:
doi:
Substances chimiques
Receptors, Ionotropic Glutamate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-92Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.