Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β-negative cognitively normal individuals.

Aged Aging / metabolism Amyloid beta-Peptides / metabolism Carbolines Cognition / physiology Female Humans Male Mental Status and Dementia Tests Neocortex / metabolism Positron-Emission Tomography Radiopharmaceuticals tau Proteins / metabolism
Mesial temporal lobe PART PET Tau

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
01 2021
Historique:
received: 06 05 2020
revised: 10 08 2020
accepted: 15 09 2020
pubmed: 2 11 2020
medline: 2 9 2021
entrez: 1 11 2020
Statut: ppublish

Résumé

We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [

Identifiants

DOI: 10.1016/j.neurobiolaging.2020.09.017 PMID: 33130455
pubmed: 33130455
pii: S0197-4580(20)30294-3
doi: 10.1016/j.neurobiolaging.2020.09.017
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Carbolines 0
Radiopharmaceuticals 0
tau Proteins 0
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole J09QS3Z3WB

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

41-48

Subventions

Organisme : NIA NIH HHS
ID : R01 AG029672
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Colin Groot (C)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address: c.groot3@amsterdamumc.nl.

Vincent Doré (V)

CSIRO Health and Biosecurity, Parkville, Victoria, Australia; Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia.

Joanne Robertson (J)

The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.

Samantha C Burnham (SC)

CSIRO Health and Biosecurity, Parkville, Victoria, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Greg Savage (G)

Department of Psychology, Macquarie University, North Ryde, New South Wales, Australia.

Rik Ossenkoppele (R)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Clinical Memory Research Unit, Lund University, P663+Q9, Lund, Sweden.

Christopher C Rowe (CC)

Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia.

Victor L Villemagne (VL)

Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Mesial temporal tau is related to worse...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Mesial temporal tau is related to worse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Mesial temporal tau is related to worse...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Carbolines › Mesial temporal tau is related to worse...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Mesial temporal tau is related to worse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mesial temporal tau is related to worse...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Tests de l'état mental et de la démence › Mesial temporal tau is related to worse...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Néocortex › Mesial temporal tau is related to worse...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Mesial temporal tau is related to worse...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Mesial temporal tau is related to worse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Mesial temporal tau is related to worse...