Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single centre experience.
Autotransfusion
COVID-19
Cytokine release syndrome (CRS)
Lipid ozonation products
Medical O3
O3 gas
O3 therapy
Oxidative stress
Reactive oxidative species
SARS-CoV-2
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
13
07
2020
accepted:
14
10
2020
pubmed:
2
11
2020
medline:
23
4
2021
entrez:
1
11
2020
Statut:
ppublish
Résumé
The emerging outbreak of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide. We prescribed some promising medication to our patients with mild to moderate pneumonia due to SARS-CoV-2, however such drugs as chloroquine, hydrossichloroquine, azithromycin, antivirals (lopinavir/ritonavir, darunavir/cobicistat) and immunomodulating agents (steroids, tocilizumab) were not confirmed as effective against SARS-CoV2. We, therefore, started to use auto-hemotherapy treated with an oxygen/ozone (O
Identifiants
pubmed: 33131033
doi: 10.1007/s11739-020-02542-6
pii: 10.1007/s11739-020-02542-6
pmc: PMC7603641
doi:
Substances chimiques
Ozone
66H7ZZK23N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
669-675Commentaires et corrections
Type : CommentIn
Références
World Health Organization. Situation updates on July 20 2020. https://www.who.int/emergiencies/disease/novel-coronavirus-2019/situation-reports/ . Accessed 20 July 2020
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C (2020) A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. https://doi.org/10.1056/NEJMoa2001282
doi: 10.1056/NEJMoa2001282
pubmed: 33356051
pmcid: 7169476
Zhang C, Wu Z, Li JW, Zhao H, Wang GQ (2020) The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. https://doi.org/10.1016/j.ijantimicag.2020.105954
doi: 10.1016/j.ijantimicag.2020.105954
pubmed: 33352235
pmcid: 7377803
Lu CC, Chen MY, Chang YL (2020) Potential therapeutic agents against COVID-19: what we know so far. J Chin Med Assoc. https://doi.org/10.1097/JCMA.0000000000000318
doi: 10.1097/JCMA.0000000000000318
pubmed: 33009241
pmcid: 7526577
Fanin A, Calegari J, Beverina A et al (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19. Intern Emerg Med 15:841–843
doi: 10.1007/s11739-020-02388-y
Elvis AM, Ekta JS (2011) Ozone therapy: a clinical review. J Nat Sci Biol Med 2:66–70
doi: 10.4103/0976-9668.82319
Bocci AV (2006) Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 37:425–435
doi: 10.1016/j.arcmed.2005.08.006
Bocci AV, Zanardi I, Travagli V (2011) Ozone acting on human blood yelds a hormetic dose-resposne relationship. J Transl Med 9:66
doi: 10.1186/1479-5876-9-66
Rowen RJ (2019) Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience. Med Gas Res 9:232–237
pubmed: 31898609
pmcid: 7802416
Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA (2017) Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res 7(3):212–219
doi: 10.4103/2045-9912.215752
Gulmen S, Kurtoglu T, Meteoglu I, Kaya S, Okutan H (2013) Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis. J Surg Res 185:64–69
doi: 10.1016/j.jss.2013.05.085
Caliskan B, Guven A, Ozler M, Cayci T, Ozcan A, Bedir O, Surer I, Korkmaz A (2011) Ozone therapy prevents renal inflammation and fibrosis in a rat model of acute pyelonephritis. Scand J Clin Lab Invest 71:473–480
doi: 10.3109/00365513.2011.587022
Ricevuti G, Franzini M, Valdenassi L (2020) Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures. Ozone Ther. https://doi.org/10.4081/ozone.2020.9014
doi: 10.4081/ozone.2020.9014
https://www.simeu.it/w/articoli/leggiArticolo/3964/leggi
R Core Team. R: a language and environment for statistical computing. Vienna, Austria. 2013. https://www.R-project.org/
https://coronavirus.jhu.edu/data/mortality
Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A, COVID-19 Lombardy ICU Network (2020) Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. https://doi.org/10.1001/jama.2020.5394
doi: 10.1001/jama.2020.5394
pubmed: 32250385
pmcid: 7136855
Perlini S, Canevari F, Cortesi S et al (2020) Emergency department and out-of-hospital emergency system (112—AREU 118) integrated response to Coronavirus disease 2019 in a Northern Italy centre. Intern Emerg Med 15:825–833
doi: 10.1007/s11739-020-02390-4
Erika P, Andrea V, Cillis MG et al (2020) Triage decision-making at the time of COVID-19 infection: the Piacenza strategy. Intern Emerg Med 15:879–882
doi: 10.1007/s11739-020-02350-y
Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure FX, Nicastri E, Oda R, Yo K, Quiros-Roldan E, Studemeister A, Redinski J, Ahmed S, Bernett J, Chelliah D, Chen D, Chihara S, Cohen SH, Cunningham J, D’Arminio Monforte A, Ismail S, Kato H, Lapadula G, L’Her E, Maeno T, Majumder S, Massari M, Mora-Rillo M, Mutoh Y, Nguyen D, Verweij E, Zoufaly A, Osinusi AO, DeZure A, Zhao Y, Zhong L, Chokkalingam A, Elboudwarej E, Telep L, Timbs L, Henne I, Sellers S, Cao H, Tan SK, Winterbourne L, Desai P, Mera R, Gaggar A, Myers RP, Brainard DM, Childs R, Flanigan T (2020) Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. https://doi.org/10.1056/NEJMoa2007016
doi: 10.1056/NEJMoa2007016
pubmed: 32412709
pmcid: 7169476
World Health Organization. Clinical management of COVID-19—interim guidance. https://www.who.int/publications/i/item/clinical-management-of-covid-19
Leon OS, Menendez S, Merino N, Castillo R, Sam S, Perez L, Cruz E, Bocci V (1998) Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators Inflamm 7:289–294
doi: 10.1080/09629359890983
Clavo B, Rodriguez-Esparragon F, Rodriguez-Abreu D, Martinez-Sanchez G, Llontop P, Aguiar-Bujanda D, Fernandez-Perez L, Santana-Rodriguez N (2019) Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: review and prospects. Antioxidants (Basel) 8:588
doi: 10.3390/antiox8120588
Rowen RJ, Robins H, Carew K, Kamara MM, Jalloh MI (2016) Rapid resolution of haemorrhagic fever (Ebola) in Sierra Leone with ozone therapy. Afr J Infect Dis 10:49–54