Multisystem inflammatory syndrome in children associated with novel coronavirus SARS-CoV-2: Presentations to a pediatric emergency department in Michigan.
Journal
The American journal of emergency medicine
ISSN: 1532-8171
Titre abrégé: Am J Emerg Med
Pays: United States
ID NLM: 8309942
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
25
06
2020
revised:
18
10
2020
accepted:
20
10
2020
pubmed:
3
11
2020
medline:
23
12
2020
entrez:
2
11
2020
Statut:
ppublish
Résumé
The SARS-CoV-2 is a respiratory virus of the coronavirus family responsible for a global pandemic since December 2019. More than 35 million people have been affected with the novel coronavirus disease (COVID-19), with more than one million deaths worldwide. Michigan was one of the top three states in the United States that was severely affected by the SAR-CoV-2 pandemic with more than 7000 deaths in adults and greater than 145,000 confirmed infections. However, compared to adults, the majority of children until recently were either asymptomatic or had a mild illness with SARS-CoV-2. Recently, a rare but potentially serious presentation associated with SARS-CoV-2 called multisystem inflammatory syndrome in children (MIS-C) has been recently reported and the Centers for Disease Control (CDC) released a case definition for the same. We report the clinical and laboratory presentations and outcomes of 34 children with MIS-C who were evaluated within a 12 week period at a pediatric emergency department (PED) of single institution in Michigan. These cases presented approximately three weeks after the peak of adult SAR-CoV-2 related deaths occurred in the state. While many children presented with clinical characteristics similar to incomplete Kawasaki disease (KD), they also exhibited certain unique features which differentiated MIS-C from KD. The information presented below will aid clinicians with early recognition, evaluation and management of MIS-C in the emergency department.
Identifiants
pubmed: 33131972
pii: S0735-6757(20)30931-1
doi: 10.1016/j.ajem.2020.10.035
pmc: PMC7585495
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
164-167Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Usha Sethuraman – No conflicts of interest. Nirupama Kannikeswaran- No conflict of interest. Jocelyn Ang- No conflict of interest. Adam Singer- No conflict of interest. Jason Patrick Miller- No conflict of interest. Rita Haddad- No conflict of interest. Curt Stankovic – No conflict of interest.
Références
J Pediatric Infect Dis Soc. 2017 Nov 24;6(4):386-388
pubmed: 28177492
Circulation. 2020 Jun 9;141(23):1903-1914
pubmed: 32297796
Pediatrics. 2009 May;123(5):e783-9
pubmed: 19403470
Lancet. 2020 May 23;395(10237):1607-1608
pubmed: 32386565
Pediatrics. 2020 Jun;145(6):
pubmed: 32179660
J Pediatr. 2020 Sep;224:24-29
pubmed: 32553861
MMWR Morb Mortal Wkly Rep. 2020 Oct 09;69(40):1450-1456
pubmed: 33031361
Circulation. 2017 Apr 25;135(17):e927-e999
pubmed: 28356445
Signal Transduct Target Ther. 2020 Mar 27;5(1):33
pubmed: 32296069
J Pediatr. 2020 Aug;223:199-203.e1
pubmed: 32405091
Pediatr Cardiol. 1999 May-Jun;20(3):184-8
pubmed: 10089241
Clin Rheumatol. 2017 Jan;36(1):223-228
pubmed: 27230223
Diagnosis (Berl). 2020 May 26;7(2):91-96
pubmed: 32352401
JAMA. 2020 Jul 21;324(3):259-269
pubmed: 32511692
Pediatr Cardiol. 2001 Mar-Apr;22(2):102-6
pubmed: 11178661
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
Ther Apher Dial. 2015 Apr;19(2):171-7
pubmed: 25257673
Lancet. 2020 Jun 6;395(10239):1771-1778
pubmed: 32410760