Clearance of Hepatitis C Virus (HCV) Is Associated With Improved Outcomes in HCV-Associated Lymphoma.
Adolescent
Adult
Aged
Aged, 80 and over
Antiviral Agents
/ therapeutic use
Black People
/ statistics & numerical data
Female
Hepacivirus
/ genetics
Hepatitis C
/ drug therapy
Humans
Lymphoma, Non-Hodgkin
/ mortality
Male
Middle Aged
Progression-Free Survival
RNA, Viral
/ isolation & purification
Retrospective Studies
Young Adult
Black
Chemoimmunotherapy
Diffuse large B cell lymphoma
Directly acting antiviral therapy
Non-Hodgkin's lymphoma
Journal
Clinical lymphoma, myeloma & leukemia
ISSN: 2152-2669
Titre abrégé: Clin Lymphoma Myeloma Leuk
Pays: United States
ID NLM: 101525386
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
11
08
2020
revised:
13
09
2020
accepted:
28
09
2020
pubmed:
3
11
2020
medline:
18
12
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Improved hepatitis C virus (HCV) clearance due to directly acting antiviral agents has led to remarkably improved outcomes of indolent HCV-associated non-Hodgkin lymphoma (NHL). The impact of directly acting antivirals on the outcomes of aggressive NHL is still under investigation. Characteristics of HCV-associated NHL in black patients are not well characterized. We report outcomes of HCV-associated NHL compared to their HCV-negative counterparts in a predominantly black population. Patients with lymphoma between January 2007 and December 2017 were retrospectively studied. Depending on presence or absence of HCV RNA, patients were grouped into HCV positive (HCV Of 397 patients with lymphoma, 40 had HCV. Black comprised 90% of HCV HCV clearance is positively associated with lymphoma outcomes in black patients. Patients who clear HCV have noninferior outcomes to HCV
Sections du résumé
BACKGROUND
Improved hepatitis C virus (HCV) clearance due to directly acting antiviral agents has led to remarkably improved outcomes of indolent HCV-associated non-Hodgkin lymphoma (NHL). The impact of directly acting antivirals on the outcomes of aggressive NHL is still under investigation. Characteristics of HCV-associated NHL in black patients are not well characterized. We report outcomes of HCV-associated NHL compared to their HCV-negative counterparts in a predominantly black population.
PATIENTS AND METHODS
Patients with lymphoma between January 2007 and December 2017 were retrospectively studied. Depending on presence or absence of HCV RNA, patients were grouped into HCV positive (HCV
RESULTS
Of 397 patients with lymphoma, 40 had HCV. Black comprised 90% of HCV
CONCLUSION
HCV clearance is positively associated with lymphoma outcomes in black patients. Patients who clear HCV have noninferior outcomes to HCV
Identifiants
pubmed: 33132102
pii: S2152-2650(20)30549-8
doi: 10.1016/j.clml.2020.09.011
pii:
doi:
Substances chimiques
Antiviral Agents
0
RNA, Viral
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e185-e193Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.