The role of inflammaging and advanced glycation end products on paratonia in patients with dementia.
Advanced glycation end-products
Dementia
Inflammation
Oxidative stress
Paratonia
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
26
06
2020
revised:
13
10
2020
accepted:
15
10
2020
pubmed:
3
11
2020
medline:
28
4
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.
Identifiants
pubmed: 33132147
pii: S0531-5565(20)30473-3
doi: 10.1016/j.exger.2020.111125
pii:
doi:
Substances chimiques
Glycation End Products, Advanced
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111125Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.