Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment.
Autophagy
Blood-brain barrier
Chronic cerebral hypoperfusion
Cognitive impairment
Environmental enrichment
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
20 11 2020
20 11 2020
Historique:
received:
06
10
2020
accepted:
15
10
2020
pubmed:
3
11
2020
medline:
1
5
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease, and the cognitive impairment is one of the common effects of VCI. Unfortunately, it lacks effective therapeutic treatments at present. In our previous study, environmental enrichment (EE), as an early intervention for lifestyle modification, can ameliorate cognitive impairment by attenuating hippocampal blood-brain barrier (BBB) injury in chronic cerebral hypoperfusion (CCH) rats. However, the underlying mechanism remains unclear. Here, we found CCH rats in the standard environment (SE) developed cognitive impairment and BBB damage, which were significantly alleviated with the EE intervention. Meantime, EE improved the autophagy dysfunction caused by CCH in the hippocampus of rats, suggesting that the effect of EE on cognitive function and BBB may be related to the improvement of autophagy pathway.
Identifiants
pubmed: 33132180
pii: S0304-3940(20)30707-2
doi: 10.1016/j.neulet.2020.135437
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
135437Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.