β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood-Brain Barrier Opening in Alzheimer's Disease.
Alzheimer’s disease
FUS
blood-brain barrier
focused ultrasound
hippocampus
β-amyloid reduction
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
08
2020
accepted:
15
09
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
epublish
Résumé
The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibility of FUS-induced BBB opening in the hippocampus and entorhinal cortex in six participants with early AD. We now report the effect of BBB opening with FUS treatment on β-amyloid plaque. Six participants underwent
Identifiants
pubmed: 33132889
doi: 10.3389/fnhum.2020.593672
pmc: PMC7575813
doi:
Types de publication
Journal Article
Langues
eng
Pagination
593672Subventions
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Informations de copyright
Copyright © 2020 D’Haese, Ranjan, Song, Haut, Carpenter, Dieb, Najib, Wang, Mehta, Chazen, Hodder, Claassen, Kaplitt and Rezai.
Références
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9180-9182
pubmed: 32284421
Med Phys. 2004 May;31(5):1083-92
pubmed: 15191296
Nat Commun. 2018 Jul 25;9(1):2336
pubmed: 30046032
Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000
pubmed: 22441582
Radiology. 2014 Dec;273(3):736-45
pubmed: 25222068
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Lancet Neurol. 2008 Feb;7(2):129-35
pubmed: 18191617
Epilepsia. 2000 Oct;41(10):1350-6
pubmed: 11051134
Alzheimers Dement (N Y). 2019 Jul 09;5:272-293
pubmed: 31334330
IEEE Trans Med Imaging. 2003 Nov;22(11):1470-9
pubmed: 14606680