Dissociating Slow Responses From Slow Responding.
attention-deficit/hyperactivity disorder (ADHD)
ex-Gaussian modeling
intra-subject variability
principal components analyses
response speed
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
10
2019
accepted:
21
08
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
epublish
Résumé
Increased Intra-Subject Variability (ISV) is a candidate endophenotype of ADHD. ISV's relationship with response speed is highly relevant for ADHD as patients are highly variable but typically no slower than controls. This brief report addresses the relationship between variability and speed by employing dimensional analyses for differentiated performance measures, with a particular focus on the ex-Gaussian measures, across relevant ADHD studies and in young healthy adults (N = 70). For both patients with ADHD and healthy adults, we found that reaction time standard deviation and mean reaction time were strongly correlated, thus failing to dissociate, but ex-Gaussian tau (τ) shared only little variance with Gaussian mu (μ), thus dissociating slow responses (τ) from response speed or-if given-slow responding (μ). Our results highlight the utility of employing the ex-Gaussian measures to disentangle ISV and speed, particularly for ADHD data as patients make more slow responses but are not overall slower than typical controls.
Identifiants
pubmed: 33132925
doi: 10.3389/fpsyt.2020.505800
pmc: PMC7562713
doi:
Types de publication
Journal Article
Langues
eng
Pagination
505800Informations de copyright
Copyright © 2020 Salunkhe, Feige, Saville, Stefanou, Linden, Bender, Berger, Smyrnis, Biscaldi and Klein.
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