Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells.
calcitriol
cell proliferation
cell survival
malignant pleural mesothelioma
mitochondria
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
05
2020
accepted:
28
08
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
22
5
2021
Statut:
epublish
Résumé
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options. The biologically active form of vitamin D, calcitriol, exerts anticancer effects in many cell types, both alone and in combination with chemotherapy drugs, through binding to vitamin D receptor (VDR); however, the role of calcitriol in MPM is still unknown. This study aimed to determine the potential antitumor role of calcitriol in MPM. The results showed that calcitriol reduces cell viability and proliferation in human MPM cells lines, which express both cytoplasmic and nuclear VDR; furthermore, calcitriol potentiated the inhibitory activity of the chemotherapy drug PEM. These effects were paralleled by cell cycle arrest and inhibition in expression of c-Myc and cyclins involved in cell cycle progression. Exposure of MPM cells to calcitriol also produced an alteration in mitochondrial function and inhibition in the expression of respiratory chain complex subunits. Finally, the inhibitory effects of calcitriol were also observed on viability of human primary MPM cells. Collectively, these results indicate a novel anticancer role for calcitriol in MPM, suggesting potential for vitamin D derivatives, alone or in combination with chemotherapy, in the treatment of this malignancy.
Identifiants
pubmed: 33133014
doi: 10.3389/fendo.2020.559586
pmc: PMC7579995
doi:
Substances chimiques
Vitamins
0
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
559586Informations de copyright
Copyright © 2020 Gesmundo, Silvagno, Banfi, Monica, Fanciulli, Gamba, Congiusta, Libener, Riganti, Ghigo and Granata.
Références
J Steroid Biochem Mol Biol. 2019 Mar;187:97-105
pubmed: 30465855
Arch Biochem Biophys. 2012 Jul 1;523(1):123-33
pubmed: 22503810
Am J Cancer Res. 2017 Aug 01;7(8):1724-1737
pubmed: 28861328
Med Sci Monit. 2019 Aug 08;25:5892-5902
pubmed: 31391414
Nat Rev Cancer. 2007 Sep;7(9):684-700
pubmed: 17721433
Anal Biochem. 2018 Jul 1;552:50-59
pubmed: 28711444
CA Cancer J Clin. 2019 Sep;69(5):402-429
pubmed: 31283845
Semin Cancer Biol. 2020 May 30;:
pubmed: 32485310
Cancers (Basel). 2019 Nov 06;11(11):
pubmed: 31698751
EBioMedicine. 2019 Jul;45:563-577
pubmed: 31278070
Nat Rev Cancer. 2014 May;14(5):342-57
pubmed: 24705652
Lung Cancer. 2012 Aug;77(2):265-71
pubmed: 22564539
Endocrinology. 2009 May;150(5):2046-54
pubmed: 19164469
Perit Dial Int. 2013 Mar-Apr;33(2):132-42
pubmed: 23032084
Cancer Lett. 2019 May 1;449:252-262
pubmed: 30790678
Mol Med Rep. 2017 Apr;15(4):2273-2279
pubmed: 28259913
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
PLoS One. 2014 Dec 29;9(12):e115816
pubmed: 25546457
BMC Cancer. 2015 Dec 18;15:983
pubmed: 26680231
Arch Pathol Lab Med. 2018 Jan;142(1):89-108
pubmed: 28686500
Steroids. 2013 Feb;78(2):127-36
pubmed: 23178257
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2226-2231
pubmed: 30659154
Eur Respir Rev. 2018 Mar 14;27(147):
pubmed: 29540495
Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1389-1397
pubmed: 31158387
J Biol Chem. 1992 Oct 5;267(28):20082-6
pubmed: 1328192
Nutrients. 2020 Jun 17;12(6):
pubmed: 32560347
Bone Rep. 2018 Jun 13;9:110-119
pubmed: 30591928
EMBO J. 1999 Oct 1;18(19):5310-20
pubmed: 10508164
Mol Cell Endocrinol. 2016 Feb 15;422:18-30
pubmed: 26586206
Eur J Nutr. 2015 Sep;54(6):1001-12
pubmed: 25296887
J Steroid Biochem Mol Biol. 2011 Jan;123(1-2):30-6
pubmed: 20955794
Carcinogenesis. 2013 Jul;34(7):1413-9
pubmed: 23677068
Endocrinology. 2012 Jun;153(6):2576-87
pubmed: 22454149
J Steroid Biochem Mol Biol. 2014 Mar;140:26-33
pubmed: 24269839
Respir Res. 2019 Nov 27;20(1):266
pubmed: 31775746
Endocrinol Metab Clin North Am. 2017 Dec;46(4):1009-1038
pubmed: 29080633
Phytother Res. 2010 Sep;24(9):1317-21
pubmed: 20127663
Life Sci. 2009 May 8;84(19-20):650-6
pubmed: 19232361
Anticancer Res. 2012 Jan;32(1):211-21
pubmed: 22213310
Cancer Res. 2010 Jan 15;70(2):440-6
pubmed: 20068163
Nutr Cancer. 2014;66(3):383-7
pubmed: 24564337
Int J Oncol. 2018 Feb;52(2):337-366
pubmed: 29345296
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32
pubmed: 23112173
J Steroid Biochem Mol Biol. 2017 Mar;167:203-218
pubmed: 27913313
Int J Mol Sci. 2018 Jun 05;19(6):
pubmed: 29874855
Int J Mol Sci. 2018 Sep 13;19(9):
pubmed: 30216977
Exp Dermatol. 2015 Oct;24(10):748-53
pubmed: 26010336
Cell Immunol. 2011;271(1):173-9
pubmed: 21788014
Drug Discov Today. 2014 Nov;19(11):1769-1774
pubmed: 24947685
Mol Endocrinol. 2010 Jan;24(1):128-47
pubmed: 19897601
Cancer Lett. 1997 Nov 25;120(1):65-9
pubmed: 9570387
Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C378-84
pubmed: 25500741