Assessing the yield and safety of endoscopy in acute graft-
Colonoscopy
Endoscopy
Esophagogastroduodenoscopy
Flexible sigmoidoscopy
Graft-vs-host disease
Hematopoietic stem cell transplant
Malignancy
Neutropenia
Stem cell transplant
Thrombocytopenia
Journal
World journal of gastrointestinal endoscopy
ISSN: 1948-5190
Titre abrégé: World J Gastrointest Endosc
Pays: United States
ID NLM: 101532474
Informations de publication
Date de publication:
16 Oct 2020
16 Oct 2020
Historique:
received:
22
07
2020
revised:
28
08
2020
accepted:
08
09
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
ppublish
Résumé
Acute gastrointestinal (GI) graft- To understand the diagnostic value of symptoms and gross endoscopic findings as well as safety of endoscopy in aGVHD patients. We analyzed 195 endoscopies performed at City of Hope in patients who underwent allogeneic HSCT less than 100 d prior for hematologic malignancy and were subsequently evaluated for aGVHD Combined esophagogastroduodenoscopy (EGD) and flexible sigmoidoscopy (FS) demonstrated a greater diagnostic yield for aGVHD (83.1%) compared to EGD (66.7%) or FS (77.2%) alone with any presenting symptom. The upper and lower GI tract demonstrated similar yields regardless of whether patients presented with diarrhea (95.7% Combined EGD and FS with biopsies of normal and inflamed mucosa demonstrated the greatest diagnostic yield regardless of presenting symptom and appears to be safe in this population of patients.
Sections du résumé
BACKGROUND
BACKGROUND
Acute gastrointestinal (GI) graft-
AIM
OBJECTIVE
To understand the diagnostic value of symptoms and gross endoscopic findings as well as safety of endoscopy in aGVHD patients.
METHODS
METHODS
We analyzed 195 endoscopies performed at City of Hope in patients who underwent allogeneic HSCT less than 100 d prior for hematologic malignancy and were subsequently evaluated for aGVHD
RESULTS
RESULTS
Combined esophagogastroduodenoscopy (EGD) and flexible sigmoidoscopy (FS) demonstrated a greater diagnostic yield for aGVHD (83.1%) compared to EGD (66.7%) or FS (77.2%) alone with any presenting symptom. The upper and lower GI tract demonstrated similar yields regardless of whether patients presented with diarrhea (95.7%
CONCLUSION
CONCLUSIONS
Combined EGD and FS with biopsies of normal and inflamed mucosa demonstrated the greatest diagnostic yield regardless of presenting symptom and appears to be safe in this population of patients.
Identifiants
pubmed: 33133371
doi: 10.4253/wjge.v12.i10.341
pmc: PMC7579526
doi:
Types de publication
Journal Article
Langues
eng
Pagination
341-354Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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