Metabolomic profiling of liver tissues after acute administration of vardenafil in rats.
Erectile dysfunction
Kreb’s cycle
Metabolomics
Q-TOF MS
Vardenafil
Journal
Veterinary research forum : an international quarterly journal
ISSN: 2008-8140
Titre abrégé: Vet Res Forum
Pays: Iran
ID NLM: 101625812
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
10
2018
accepted:
19
01
2019
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
ppublish
Résumé
Erectile dysfunction (ED) diseases have almost affected 100 million men all over the world. Orally administered phosphodiesterase 5 (PDE 5) inhibitors are the most used pharmaceutical formulations for the treatment of ED. In this study, it is aimed to investigate the metabolomics feature of orally administered vardenafil in rats. To carry out the experimental procedure eight male Wistar albino rats were used. Their livers were gently removed and metabolomics profiles of each sample were determined by UPLC Q-TOF MS. Identification of metabolites was achieved by the METLIN database. Cluster analysis was also performed via Principle Component Analysis. Several metabolites were identified and results were evaluated by XCMS software. UPLC Q-TOF MS could be successfully applied to profile biomarkers and help us understand the molecular mechanisms of vardenafil usage. It was concluded that the level of some metabolites, responsible for the collagen synthesis and Kreb's cycle, has been statistically significant after the vardenafil administration.
Identifiants
pubmed: 33133457
doi: 10.30466/vrf.2019.95959.2302
pmc: PMC7597791
doi:
Types de publication
Journal Article
Langues
eng
Pagination
213-217Informations de copyright
© 2020 Urmia University. All rights reserved.
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