Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients.

benign prostate hyperplasia hypogonadism obesity obstructive sleep apnea prostate cancer prostatitis testosterone replacement therapy type 2 diabetes mellitus

Journal

Therapeutic advances in endocrinology and metabolism
ISSN: 2042-0188
Titre abrégé: Ther Adv Endocrinol Metab
Pays: United States
ID NLM: 101532143

Informations de publication

Date de publication:
2020
Historique:
received: 26 05 2020
accepted: 24 09 2020
entrez: 2 11 2020
pubmed: 3 11 2020
medline: 3 11 2020
Statut: epublish

Résumé

Male hypogonadism, defined as an inadequate production of testosterone (T), is associated with a greater morbidity and mortality. Epidemiological studies identified T deficiency as a risk factor for cardiovascular disease. Also, low serum T levels impact on glucose homeostasis through a worse glucose uptake, utilization, and disposal, and the general negative impact on metabolism. The aim of this review is to provide a comprehensive and updated overview of the effects of T replacement therapy on metabolic and cardiovascular systems and prostate tissue in patients with hypogonadism, including molecular mechanisms through which T exerts its actions. Furthermore, recent findings on novel coronavirus disease (COVID-19) epidemiology have shown a greater mortality in male compared with female patients and a role of T in promoting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection of the host cells has been demonstrated. Hence, the secondary aim of this review is to provide preliminary indications on the management in patients with COVID-19.

Identifiants

pubmed: 33133492
doi: 10.1177/2042018820966438
pii: 10.1177_2042018820966438
pmc: PMC7576928
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

2042018820966438

Informations de copyright

© The Author(s), 2020.

Déclaration de conflit d'intérêts

Conflict of interest statement: The authors declare that there is no conflict of interest.

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Auteurs

Rossella Cannarella (R)

Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy.

Aldo E Calogero (AE)

Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy.

Rosita A Condorelli (RA)

Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy.

Antonio Aversa (A)

Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.

Sandro La Vignera (S)

Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", via S. Sofia 78, Catania, Sicily 95123, Italy.

Classifications MeSH