Assessment of Melatonin and Its Precursors Content by a HPLC-MS/MS Method from Different Romanian Wines.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
27 Oct 2020
27 Oct 2020
Historique:
received:
20
07
2020
accepted:
02
10
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
epublish
Résumé
Because melatonin has strong antioxidant activity and wine is an alcoholic beverage of economic relevance, in the present work, the impact of some variable parameters that may occur in the winemaking process on the concentrations of melatonin and its precursors in Romanian wines was studied. Therefore, a sensitive and selective high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for the simultaneous analysis of melatonin, serotonin, and l-tryptophan, and some method performance parameters including selectivity, detection limit, precision (by comparing with an alternative HPLC-FL method), accuracy, and robustness were validated. These determinations are significant and the final amounts of analytes are dependent on the microorganisms involved in the winemaking process, the grape variety, geographic regions of vineyards, and aging of wines. In the future, the method may be useful to increase the melatonin content and the antioxidant activity in wines by improved steps in the winemaking process, especially based on application of selected yeasts and improved fermentation conditions.
Identifiants
pubmed: 33134687
doi: 10.1021/acsomega.0c03463
pmc: PMC7594137
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27254-27260Informations de copyright
© 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Agric Food Chem. 2016 Jun 15;64(23):4772-6
pubmed: 27148823
Molecules. 2019 Oct 08;24(19):
pubmed: 31597344
J Pineal Res. 2013 Apr;54(3):322-33
pubmed: 23171152
Electrophoresis. 2010 Jul;31(13):2242-8
pubmed: 20593400
J Pineal Res. 2011 Sep;51(2):226-32
pubmed: 21605162
Food Chem. 2017 Sep 15;231:185-191
pubmed: 28449995
J Sci Food Agric. 2015 Sep;95(12):2355-9
pubmed: 25501293
J Food Sci. 2011 Apr;76(3):C436-40
pubmed: 21535811
Pharmacol Ther. 1990;46(1):119-36
pubmed: 2181488
J Psychiatr Res. 1982-1983;17(2):123-33
pubmed: 6764929
J Pineal Res. 2014 Nov;57(4):435-41
pubmed: 25251161
J Pineal Res. 2011 Aug;51(1):1-16
pubmed: 21752095
Molecules. 2017 Feb 14;22(2):
pubmed: 28216567
Food Chem Toxicol. 2013 Jul;57:140-6
pubmed: 23531627
Foods. 2019 Mar 14;8(3):
pubmed: 30875821
J Sep Sci. 2008 Apr;31(6-7):1007-14
pubmed: 18338365
Food Chem. 2011 Jun 15;126(4):1608-13
pubmed: 25213934
Eur J Clin Nutr. 2019 Jul;72(Suppl 1):55-59
pubmed: 30487561
Antioxidants (Basel). 2019 Feb 16;8(2):
pubmed: 30781536
Electrophoresis. 2013 Jun;34(12):1749-56
pubmed: 23686585
J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):909-14
pubmed: 20547498
Pol J Pharmacol. 2004 Mar-Apr;56(2):159-70
pubmed: 15156066
J Pineal Res. 2012 Oct;53(3):219-24
pubmed: 22515683
Food Chem. 2017 Feb 15;217:431-437
pubmed: 27664655