The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy.

The SARS-Cov-2 pandemic requires special attention on its psychological effects and the impact on patients with chronic pain. This study aimed at examining the influence of the COVID-19 pandemic-associated regulations initiated by the German government on pain intensity and characteristics, emotional well-being, and everyday life of patients with painful polyneuropathy. Forty-three patients (well assessed with questionnaires before the pandemic and without change of their health status between baseline and current assessment) were investigated with validated, self-reported questionnaires and COVID-19-specific items 2 weeks after the regulations came into effect. Pain intensity remained stable or even improved like the neuropathic pain symptom inventory total score (t0: 33.54 ± 20.48 vs t1: 27.38 ± 16.16, Results suggest a shift of attention from the chronic pain condition towards the imminent threat of a global pandemic. As the impacts of the pandemic are persistent and evolving, the development of the measured parameters in the forthcoming weeks will be of great interest.

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

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This study was supported by Grünenthal GmbH Deutschland with no involvement in experimental design, conduction, or interpretation of the study. Dilara Kersebaum reports grants from Grünenthal GmbH, during the conduct of the study; Sophie-Charlotte Fabig reports grants from Grünenthal GmbH, during the conduct of the study as well as personal fees from Grünenthal GmbH outside the submitted work; Manon Sendel reports grants from Grünenthal GmbH, during the conduct of the study; personal fees from Sanofi Genzyme, personal fees from Grünethal, personal fees from AKCEA, outside the submitted work; Dr. Sachau reports grants from Grünenthal GmbH, during the conduct of the study; non-financial support from Alnylam Pharmaceuticals, non-financial support from Pfizer, personal fees from Grünenthal GmbH, outside the submitted work;. Josephine Lassen reports grants from Grünenthal GmbH, during the conduct of the study; Dr. Rehm reports grants from Grünenthal GmbH, during the conduct of the study; Dr. Huellemann reports grants from Grünenthal GmbH, during the conduct of the study; grants from BMBF, grants from Medoc , grants from Zambon, outside the submitted work; Dr. Baron reports grants from Grünenthal GmbH, during the conduct of the study; grants from EU Projects: “Europain” (115007). DOLORisk (633491). IMI Paincare (777500). German Federal Ministry of Education and Research (BMBF): Verbundprojekt: Frühdetektion von Schmerzchronifizierung (NoChro) (13GW0338C). German Research Network on Neuropathic Pain (01EM0903). Pfizer Pharma GmbH, Genzyme GmbH, Grünenthal GmbH, Mundipharma Research GmbH und Co. KG., Novartis Pharma GmbH, Alnylam Pharmaceuticals Inc., Zambon GmbH, personal fees from Pfizer Pharma GmbH, Genzyme GmbH, Grünenthal GmbH, Mundipharma, Sanofi Pasteur, Medtronic Inc. Neuromodulation, Eisai Co.Ltd., Lilly GmbH, Boehringer Ingelheim Pharma GmbH & Co. KG, Astellas Pharma GmbH, Desitin Arzneimittel GmbH, Teva GmbH, Bayer-Schering, MSD GmbH, Seqirus Australia Pty. Ltd, Novartis Pharma GmbH, TAD Pharma GmbH, Grünenthal SA Portugal, Sanofi-Aventis Deutschland GmbH, Agentur Brigitte Süss, Grünenthal Pharma AG Schweiz, Grünenthal B.V. Niederlande, personal fees from Pfizer Pharma GmbH, Genzyme GmbH, Grünenthal GmbH, Mundipharma Research GmbH und Co. KG, Allergan, Sanofi Pasteur, Medtronic, Eisai, Lilly GmbH, Boehringer Ingelheim Pharma GmbH&Co.KG, Astellas Pharma GmbH, Novartis Pharma GmbH, Bristol-Myers Squibb, Biogenidec, AstraZeneca GmbH, Merck, Abbvie, Daiichi Sankyo, Glenmark Pharmaceuticals S.A., Seqirus Australia Pty. Ltd, Teva Pharmaceuticals Europe Niederlande, Teva GmbH, Genentech, Mundipharma International Ltd. UK, Astellas Pharma Ltd. UK, Galapagos NV, Kyowa Kirin GmbH, Vertex Pharmaceuticals Inc., Biotest AG, Celgene GmbH, Desitin Arzneimittel GmbH, Regeneron Pharmaceuticals Inc. USA, Theranexus DSV CEA Frankreich, Abbott Products Operations AG Schweiz, Bayer AG, Grünenthal Pharma AG Schweiz, Mundipharma Research Ltd. UK, Akcea Therapeutics Germany GmbH, Asahi Kasei Pharma Corporation, AbbVie Deutschland GmbH & Co. KG, Air Liquide Sante International Frankreich, Alnylam Germany GmbH, Lateral Pharma Pty Ltd, Hexal AG, Ethos Srl Italien, Janssen, outside the submitted work; Dr. Gierthmühlen reports grants from Grünenthal GmbH, during the conduct of the study; personal fees from TAD Pharma, personal fees from Glenmark, Certkom, personal fees from Pfizer, Grünenthal, Sanofi Pasteur, Novartis, outside the submitted work.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.