Ischemic stroke, obesity, and the anti-inflammatory role of melatonin.
anti-inflammation
brain
ischemic stroke
melatonin
obesity
Journal
BioFactors (Oxford, England)
ISSN: 1872-8081
Titre abrégé: Biofactors
Pays: Netherlands
ID NLM: 8807441
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
02
09
2020
accepted:
14
10
2020
pubmed:
3
11
2020
medline:
10
9
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory events that occur during ischemic stroke and obesity, and we discuss the influence of obesity on the inflammatory response and cerebral damage outcomes in experimental models of brain ischemia. In addition, because melatonin is a neurohormone widely reported to exhibit protective effects in various diseases, this study also demonstrates the anti-inflammatory role and possible mechanistic actions of melatonin in both epidemic diseases. A summary of research findings suggests that melatonin administration has great potential to exert an anti-inflammatory role and provide protection against obesity and ischemic stroke conditions. However, the efficacy of this hormonal treatment on ischemic stroke with concomitant obesity, when more serious inflammation is generated, is still lacking.
Substances chimiques
Anti-Inflammatory Agents
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-58Subventions
Organisme : Royal Golden Jubilee PhD program
ID : PHD/0104/2561
Organisme : Thailand Research Fund
ID : RSA6080025
Organisme : Functional Food Research Center for Well-being
Organisme : Chiang Mai University
Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology.
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