Impact of combinations of single-nucleotide polymorphisms of anthracycline transporter genes upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia.
Adult
Humans
Anthracyclines
/ adverse effects
ATP-Binding Cassette Transporters
/ genetics
Genotype
Induction Chemotherapy
Leukemia, Myeloid, Acute
/ drug therapy
Liver-Specific Organic Anion Transporter 1
/ genetics
Multidrug Resistance-Associated Protein 2
Polymorphism, Single Nucleotide
Prospective Studies
ABCB1
SLCO1B1
SNP-SNP combination
anthracyclines
idarubicin
polymorphism
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
3
11
2020
medline:
28
4
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Anthracycline uptake could be affected by influx and efflux transporters in acute myeloid leukemia (AML). Combinations of single-nucleotide polymorphisms (SNPs) of wild-type genotype of influx transporters (
Identifiants
pubmed: 33135528
doi: 10.1080/10428194.2020.1839650
doi:
Substances chimiques
ABCC2 protein, human
0
Anthracyclines
0
ATP-Binding Cassette Transporters
0
Liver-Specific Organic Anion Transporter 1
0
Multidrug Resistance-Associated Protein 2
0
SLCO1B1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM