Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity.

Antimalarials / pharmacology Apicoplasts / drug effects Doxycycline / chemistry Molecular Structure Plasmodium falciparum / drug effects
P. falciparum apicoplast doxycycline drug mechanisms infectious disease malaria metals microbiology

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
02 11 2020
Historique:
received: 21 06 2020
accepted: 01 11 2020
pubmed: 3 11 2020
medline: 23 3 2021
entrez: 2 11 2020
Statut: epublish

Résumé

Doxycycline (DOX) is a key antimalarial drug thought to kill

Identifiants

DOI: 10.7554/eLife.60246 PMID: 33135634 PMC: PMC7669263
pubmed: 33135634
doi: 10.7554/eLife.60246
pii: 60246
pmc: PMC7669263
doi:
pii:

Substances chimiques

Antimalarials 0
Doxycycline N12000U13O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R25 HL108828
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133764
Pays : United States
Organisme : Pew Charitable Trusts
ID : 32099
Pays : International
Organisme : NIGMS NIH HHS
ID : R35GM133764
Pays : United States
Organisme : Burroughs Wellcome Fund
ID : 1011969
Pays : International
Organisme : NIDDK NIH HHS
ID : T32 DK007115
Pays : United States

Informations de copyright

© 2020, Okada et al.

Déclaration de conflit d'intérêts

MO, PG, SN, PS No competing interests declared

Références

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Auteurs

Megan Okada (M)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.

Ping Guo (P)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
ORCID: 0000-0003-3023-779X

Shai-Anne Nalder (SA)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.

Paul A Sigala (PA)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
ORCID: 0000-0002-3464-3042

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Doxycycline has distinct apicoplast-specific...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Plastes › Apicoplastes › Doxycycline has distinct apicoplast-specific...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Doxycycline › Doxycycline has distinct apicoplast-specific...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Doxycycline has distinct apicoplast-specific...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Doxycycline has distinct apicoplast-specific...