Trace level detection of select opioids (fentanyl, hydrocodone, oxycodone, and tramadol) in suspect pharmaceutical tablets using surface-enhanced Raman scattering (SERS) with handheld devices.
SERS
fentanyl
hydrocodone
opioids
oxycodone
raman handheld devices
tramadol
Journal
Journal of forensic sciences
ISSN: 1556-4029
Titre abrégé: J Forensic Sci
Pays: United States
ID NLM: 0375370
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
28
08
2020
revised:
25
09
2020
accepted:
29
09
2020
pubmed:
3
11
2020
medline:
22
6
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
The opioid crisis in the USA has resulted in over 702,000 overdose fatalities between 1999 and 2017 and can be attributed to over-prescription of opioids and abuse of synthetic opioids in combination with other illicit drugs. A rapid and sensitive SERS method has been developed for trace detection of opioids including fentanyl, hydrocodone, oxycodone, and tramadol in low-dosage suspect tablets using two different handheld Raman spectrometers equipped with 785 and 1064 nm lasers. The method involves a micro-extraction procedure using 10% methanol in deionized water, followed by filtration and addition of colloidal silver and aqueous KBr, resulting in a mixture that can be measured directly via a glass vial. The lowest concentration (C
Identifiants
pubmed: 33136297
doi: 10.1111/1556-4029.14600
doi:
Substances chimiques
Analgesics, Opioid
0
Counterfeit Drugs
0
Illicit Drugs
0
Tablets
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-504Informations de copyright
Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
Références
Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999-2017. Hyattsville, MD: National Center for Health Statistics; 2018. NCHS Data Brief, No 329. https://www.cdc.gov/nchs/products/databriefs/db329.htm. Accessed 30 Sep 2020.
CDC, National Center for Health Statistics. Wide-ranging online data for epidemiologic research (WONDER). Atlanta, GA: CDC, National Center for Health Statistics; 2018. https://healthdata.gov/dataset/wide-ranging-online-data-epidemiologic-research-wonder.
Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and opioid-involved overdose deaths - United States, 2013-2017. MMWR Morb Mortal Wkly Rep. 2019;67:1419-27. https://doi.org/10.15585/mmwr.mm675152e1.
Califf RM, Woodcock J, Ostroff S. A proactive response to prescription opioid abuse. N Engl J Med. 2016;374(15):1480-5. https://doi.org/10.1056/NEJMsr1601307.
Healthy innovations, safer families: FDA’s 2018 strategic policy roadmap; 2018. https://www.fda.gov/media/110587/download. Accessed 30 Sep 2020.
Fleischmann M, Hendra PJ, Mcquillan AJ. Raman spectra of pyridine adsorbed at a silver electrode. Chem Phys Lett. 1974;26(2):163-6. https://doi.org/10.1016/0009-2614(74)85388-1.
Jeanmaire DL, Van Duyne RP. Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. J Electroanal Chem Interfacial Electrochem. 1977;84(1):1-20. https://doi.org/10.1016/S0022-0728(77)80224-6.
Gruenke NL, Fernanda CM, McAnally MO, Frontiera RR, Schatz GC, Van Duyne RP. Ultrafast and nonlinear surface-enhanced raman spectroscopy. Chem Soc Rev. 2016;45:2263-90. https://doi.org/10.1039/C5CS00763A.
Kneipp K, Wang Y, Kneipp H, Perelman LT, Itzkan I, Dasari RR, et al. Single molecule detection using surface-enhanced raman scattering (SERS). Phys Rev Lett. 1997;78:1667-70. https://doi.org/10.1103/PhysRevLett.78.1667.
Farquharson S, Brouillette C, Smith W, Shende C. A surface-enhanced raman spectral library of important drugs associated with point-of-care and field operations. Front Chem. 2019;7:706. https://doi.org/10.3389/fchem.2019.00706.
Lanzarotta A, Lorenz L, Batson J, Flurer C. Development and implementation of a pass/fail field-friendly method for detecting sildenafil in suspect pharmaceutical tablets using a handheld raman spectrometer and silver colloids. J Pharm Biomed Anal. 2017;146:420-5. https://doi.org/10.1016/j.jpba.2017.09.005.
Han Z, Liu H, Meng J, Yang L, Liu J. Portable kit for identification and detection of drugs in human urine using surface-enhanced raman spectroscopy. Anal Chem. 2015;87(18):9500-6. https://doi.org/10.1021/acs.analchem.5b02899.
Dong R, Weng S, Yang L, Liu J. Detection and direct readout of drugs in human urine using dynamic surface-enhanced raman spectroscopy and support vector machines. Anal Chem. 2015;87(5):2937-44. https://doi.org/10.1021/acs.analchem.5b00137.
Zong C, Xu M, Xu L, Wei T, Ma X, Zheng X, et al. Surface enhanced raman spectroscopy for bioanalysis: reliability and challenges. Chem Rev. 2018;118(10):4946-80. https://doi.org/10.1021/acs.chemrev.7b00668.
Yu B, Ge M, Li P, Xie Q, Yang L. Development of surface-enhanced raman spectroscopy application for determination of illicit drugs: towards a practical sensor. Talanta. 2019;191:1-10. https://doi.org/10.1016/j.talanta.2018.08.032.
Lanzarotta, A, Thatcher, MD, Lorenz, LM, Batson, JS. Detection of mitragynine in mitragyna speciosa (kratom) using surface-enhanced raman spectroscopy with handheld devices. J Forensic Sci. 2020;65: 1443-1449. https://doi.org/10.1111/1556-4029.14457.
De Ruig WG, Dijkstra G, Stephany RW. Chemometric criteria for assessing the certainty of qualitative analytical methods. Anal Chim Acta. 1989;223:277-82. https://doi.org/10.1016/S0003-2670(00)84091-X.
Hester RE, Plane RA. Raman spectra of methanol solutions: saturated solutions of some electrolytes. Spectrochim Acta A: Mol Spectrosc. 1967;23(8):2289-96. https://doi.org/10.1016/0584-8539(67)80121-1.
Cyrankiewicz M, Wybranowski T, Kruszewski S. Study of SERS efficiency of metallic colloidal systems. J Phys Conf Ser. 2007;79:012013. https://doi.org/10.1088/1742-6596/79/1/012013.
Dollish F, Fately W, Bentley F. Characteristic raman frequencies of organic compounds. New York, NY: Wiley; 1974. p. 215-83.
Leonard J, Haddad A, Green O, Birke R, Kubic T, Kocak A, et al. SERS, raman, and DFT analyses of fentanyl and carfentanyl: towards detection of trace samples. J Raman Spectrosc. 2017;48:1323-9. https://doi.org/10.1002/jrs.5220.
Shende C, Brouillette C, Farquharson S. Detection of codeine and fentanyl in saliva, blood plasma and whole blood in 5-minutes using a SERS flow-separation strip. Analyst. 2019;144(18):5449-54. https://doi.org/10.1039/C9AN01087D.
Rana V, Canamares MV, Kubic T, Leona M, Lombardi JR. Surface-enhanced raman spectroscopy for trace identification of controlled substances: morphine, codeine, and hydrocodone. J Forensic Sci. 2011;56(1):200-7. https://doi.org/10.1111/j.1556-4029.2010.01562.x.
Tavakol H, Esfandyari M, Taheri S, Heydari A. Investigation of structure, vibrational and NMR spectra of oxycodone and naltrexone: a combined experimental and theoretical study. Spectrochim Acta A Mol Biomol Spectrosc. 2011;79(3):574-82. https://doi.org/10.1016/j.saa.2011.03.038.
Alharbi O, Xu Y, Goodacre R. Detection and quantification of the opioid tramadol in urine using surface enhanced raman scattering. Analyst. 2015;140:5965-70. https://doi.org/10.1039/C5AN01177A.