SERUM LEVELS OF ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES ARE DECREASED IN PATIENTS WITH RETINAL VEIN OCCLUSION.
Aged
Antibodies, Anti-Idiotypic
/ blood
Biomarkers
/ blood
Cross-Sectional Studies
Disease Progression
Enzyme-Linked Immunosorbent Assay
Epitopes
/ blood
Female
Fluorescein Angiography
/ methods
Follow-Up Studies
Fundus Oculi
Humans
Immunoglobulin M
/ blood
Lipoproteins, LDL
/ blood
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
/ immunology
Prospective Studies
Retinal Vein Occlusion
/ blood
Tomography, Optical Coherence
/ methods
Journal
Retina (Philadelphia, Pa.)
ISSN: 1539-2864
Titre abrégé: Retina
Pays: United States
ID NLM: 8309919
Informations de publication
Date de publication:
01 Jun 2021
01 Jun 2021
Historique:
pubmed:
3
11
2020
medline:
15
12
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Oxidative stress and inflammation have been implicated in the development of retinal vein occlusion (RVO). Oxidation-specific epitopes (OSEs) represent products of oxidative stress that can trigger vascular inflammation and thrombosis. Natural occurring antibodies have been shown to bind oxidation-specific epitopes thereby inhibiting their inflammatory potential and promoting their removal. This prospective cross-sectional study included 270 patients with RVO and 81 in-hospital control patients. We measured three types of serum levels of oxidation-specific epitope-specific immunoglobulin M and immunoglobulin G antibodies (anti-copper-oxidized LDL [CuOx-LDL], antiphosphocholine [PC], anti-malondialdehyde-modified LDL [MDA-LDL]). History of arterial hypertension, hyperlipidemia, myocardial infarction, diabetes mellitus, stroke, smoking status, and several laboratory parameters were determined to control for potential confounders. Compared with controls, patients with RVO had significantly lower levels of immunoglobulin M and immunoglobulin G antibodies against CuOx-LDL and PC, and significantly lower levels of immunoglobulin G but not immunoglobulin M antibodies against MDA-LDL. The association between RVO patients and lower levels of these antibodies prevailed upon multivariable adjustment. These prospective data show that antibodies against oxidation-specific epitope are lower in patients with RVO compared with control patients and support the concept that oxidative stress and inflammation play key roles in the development and subsequent complications in RVO.
Identifiants
pubmed: 33136978
pii: 00006982-202106000-00007
doi: 10.1097/IAE.0000000000003001
doi:
Substances chimiques
Antibodies, Anti-Idiotypic
0
Biomarkers
0
Epitopes
0
Immunoglobulin M
0
Lipoproteins, LDL
0
oxidized low density lipoprotein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1193-1201Références
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