Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.

AMP-Activated Protein Kinases Creatinine Genome-Wide Association Study Glomerular Filtration Rate / genetics Humans Kidney Protein Disulfide-Isomerases United Kingdom
acute kidney injury end-stage kidney disease genome-wide association study rapid eGFRcrea decline

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
04 2021
Historique:
received: 04 06 2020
revised: 21 08 2020
accepted: 17 09 2020
pubmed: 3 11 2020
medline: 22 6 2021
entrez: 2 11 2020
Statut: ppublish

Résumé

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m

Identifiants

DOI: 10.1016/j.kint.2020.09.030 PMID: 33137338 PMC: PMC8010357
pubmed: 33137338
pii: S0085-2538(20)31239-4
doi: 10.1016/j.kint.2020.09.030
pmc: PMC8010357
mid: NIHMS1677067
pii:
doi:

Substances chimiques

Creatinine AYI8EX34EU
PRKAG2 protein, human EC 2.7.11.1
AMP-Activated Protein Kinases EC 2.7.11.31
PDILT protein, human EC 5.3.4.1
Protein Disulfide-Isomerases EC 5.3.4.1

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

926-939

Subventions

Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85083
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089951
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007417
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL103612
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081802
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200800007C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U19 HL065962
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800015I
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA160056
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025141
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110113
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107786
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087652
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004402
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL129982
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM062459
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC55222
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NHLBI NIH HHS
ID : HHSN268201200036C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NIMHD NIH HHS
ID : P20 MD006899
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101855
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM010098
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD074711
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIGMS NIH HHS
ID : RC2 GM092618
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124097
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006378
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS032830
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004798
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087641
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NIMHD NIH HHS
ID : HHSN268201800013I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States

Investigateurs

Behrooz Z Alizadeh (BZ)
H Marike Boezen (HM)
Lude Franke (L)
Pim van der Harst (P)
Gerjan Navis (G)
Marianne Rots (M)
Harold Snieder (H)
Morris Swertz (M)
Bruce H R Wolffenbuttel (BHR)
Cisca Wijmenga (C)
Goncalo Abecasis (G)
Aris Baras (A)
Michael Cantor (M)
Giovanni Coppola (G)
Aris Economides (A)
Luca A Lotta (LA)
John D Overton (JD)
Jeffrey G Reid (JG)
Alan Shuldiner (A)
Christina Beechert (C)
Caitlin Forsythe (C)
Erin D Fuller (ED)
Zhenhua Gu (Z)
Michael Lattari (M)
Alexander Lopez (A)
John D Overton (JD)
Thomas D Schleicher (TD)
Maria Sotiropoulos Padilla (MS)
Karina Toledo (K)
Louis Widom (L)
Sarah E Wolf (SE)
Manasi Pradhan (M)
Kia Manoochehri (K)
Ricardo H Ulloa (RH)
Xiaodong Bai (X)
Suganthi Balasubramanian (S)
Leland Barnard (L)
Andrew Blumenfeld (A)
Gisu Eom (G)
Lukas Habegger (L)
Alicia Hawes (A)
Shareef Khalid (S)
Jeffrey G Reid (JG)
Evan K Maxwell (EK)
William Salerno (W)
Jeffrey C Staples (JC)
Marcus B Jones (MB)
Lyndon J Mitnaul (LJ)

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 International Society of Nephrology. All rights reserved.

Références

Int J Epidemiol. 2015 Aug;44(4):1137-47
pubmed: 24518929
PLoS Genet. 2019 Dec 12;15(12):e1008489
pubmed: 31830040
Nat Commun. 2019 Aug 26;10(1):3842
pubmed: 31451708
Kidney Int. 2015 May;87(5):1017-29
pubmed: 25493955
J Am Soc Nephrol. 2017 Mar;28(3):923-934
pubmed: 27729571
BMJ Open. 2019 Sep 20;9(9):e030596
pubmed: 31542753
Am J Kidney Dis. 2020 Jan;75(1):84-104
pubmed: 31473020
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Hum Genet. 2016 Nov;135(11):1251-1262
pubmed: 27461219
Eur J Epidemiol. 2014 May;29(5):371-82
pubmed: 24840228
Nat Genet. 2012 Dec;44(12):1294-301
pubmed: 23104008
Kidney Int. 2011 Jun;79(12):1331-40
pubmed: 21289598
Kidney Int. 2020 Feb;97(2):236-242
pubmed: 31980069
PLoS Genet. 2011 Sep;7(9):e1002292
pubmed: 21980298
N Engl J Med. 2012 Dec 20;367(25):2407-18
pubmed: 23121377
Lancet. 2019 Jan 5;393(10166):31-39
pubmed: 30424892
PLoS One. 2014 Feb 13;9(2):e88273
pubmed: 24551085
PLoS Genet. 2012 Sep;8(9):e1002921
pubmed: 23028342
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Nucleic Acids Res. 2019 Jan 8;47(D1):D801-D806
pubmed: 30407599
Int J Clin Pharmacol Ther. 2006 Aug;44(8):364-74
pubmed: 16961167
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
Kidney Blood Press Res. 2004;27(4):259-66
pubmed: 15316128
J Am Soc Nephrol. 2019 Oct;30(10):2000-2016
pubmed: 31537649
Am J Hum Genet. 2018 Aug 2;103(2):232-244
pubmed: 30057032
Nat Genet. 2019 Jun;51(6):957-972
pubmed: 31152163
Curr Protoc Bioinformatics. 2017 Jun 27;58:1.2.1-1.2.12
pubmed: 28654725
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Nat Rev Genet. 2018 Aug;19(8):491-504
pubmed: 29844615
J Am Soc Nephrol. 2017 Feb;28(2):557-574
pubmed: 27647854
Diabetologia. 2014 Aug;57(8):1611-22
pubmed: 24871321
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Am J Kidney Dis. 2010 Oct;56(4):743-58
pubmed: 20728256
Kidney Int. 2019 Jan;95(1):160-172
pubmed: 30473140
Am J Pathol. 2012 Apr;180(4):1431-40
pubmed: 22322304
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
Nephrol Dial Transplant. 2012 Oct;27(10):3835-43
pubmed: 22764191
PLoS Genet. 2015 Aug 25;11(8):e1005352
pubmed: 26305897
J Appl Physiol Respir Environ Exerc Physiol. 1981 Sep;51(3):762-6
pubmed: 7327978
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
J Am Soc Nephrol. 2009 Dec;20(12):2617-24
pubmed: 19892932
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Nat Genet. 2015 Aug;47(8):856-60
pubmed: 26121088
Nephrol Dial Transplant. 2020 May 1;35(5):803-810
pubmed: 31953939
Kidney Int. 2013 Sep;84(3):622-3
pubmed: 23989362
Am J Kidney Dis. 2014 Dec;64(6):821-35
pubmed: 25441437
Clin Immunol. 2016 Mar;164:114-8
pubmed: 26883681
Ther Apher Dial. 2020 Dec;24(6):677-687
pubmed: 31997551
JAMA. 2014 Jun 25;311(24):2518-2531
pubmed: 24892770
Kidney Int Rep. 2018 Mar 14;3(4):867-878
pubmed: 29989002

Auteurs

Mathias Gorski (M)

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Electronic address: mathias.gorski@klinik.uni-regensburg.de.

Bettina Jung (B)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

Yong Li (Y)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

Pamela R Matias-Garcia (PR)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; TUM School of Medicine, Technical University of Munich, Munich, Germany.

Matthias Wuttke (M)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany; Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

Stefan Coassin (S)

Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.

Chris H L Thio (CHL)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Marcus E Kleber (ME)

Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Thomas W Winkler (TW)

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

Veronika Wanner (V)

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

Jin-Fang Chai (JF)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Audrey Y Chu (AY)

Genetics, Merck & Co., Inc., Kenilworth, New Jersey, USA.

Massimiliano Cocca (M)

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste, Italy.

Mary F Feitosa (MF)

Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.

Sahar Ghasemi (S)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Anselm Hoppmann (A)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

Katrin Horn (K)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.

Man Li (M)

Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.

Teresa Nutile (T)

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Naples, Italy.

Markus Scholz (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.

Karsten B Sieber (KB)

Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Adrienne Tin (A)

Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, Mississippi, USA; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Judy Wang (J)

Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.

Bamidele O Tayo (BO)

Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, USA.

Tarunveer S Ahluwalia (TS)

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Peter Almgren (P)

Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.

Stephan J L Bakker (SJL)

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Bernhard Banas (B)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

Nisha Bansal (N)

Division of Nephrology, University of Washington, Seattle, Washington, USA; Kidney Research Institute, University of Washington, Seattle, Washington, USA.

Mary L Biggs (ML)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Eric Boerwinkle (E)

Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA.

Erwin P Bottinger (EP)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, University of Heidelberg, Heidelberg, Germany.

Robert J Carroll (RJ)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

John Chalmers (J)

The George Institute for Global Health, University of New South Wales, Sydney, Australia; The George Institute for Global Health, University of Oxford, Oxford, UK; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Miao-Li Chee (ML)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.

Miao-Ling Chee (ML)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.

Ching-Yu Cheng (CY)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.

Josef Coresh (J)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Martin H de Borst (MH)

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Frauke Degenhardt (F)

Institute of Clinical Molecular Biology, Christian-AlbrechtsUniversity of Kiel, Kiel, Germany.

Kai-Uwe Eckardt (KU)

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Karlhans Endlich (K)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.

Andre Franke (A)

Institute of Clinical Molecular Biology, Christian-AlbrechtsUniversity of Kiel, Kiel, Germany.

Sandra Freitag-Wolf (S)

Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.

Piyush Gampawar (P)

Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.

Ron T Gansevoort (RT)

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Mohsen Ghanbari (M)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

Pavel Hamet (P)

Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada; Medpharmgene, Montreal, Quebec, Canada; CRCHUM, Montreal, Canada.

Kevin Ho (K)

Kidney Health Research Institute (KHRI), Geisinger, Danville, Pennsylvania, USA; Department of Nephrology, Geisinger, Danville, Pennsylvania, USA.

Edith Hofer (E)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Bernd Holleczek (B)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Valencia Hui Xian Foo (VH)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.

Nina Hutri-Kähönen (N)

Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Shih-Jen Hwang (SJ)

NHLBI's Framingham Heart Study, Framingham, Massachusetts, USA; The Center for Population Studies, NHLBI, Framingham, Massachusetts, USA.

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Navya Shilpa Josyula (NS)

Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, Maryland, USA.

Mika Kähönen (M)

Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Chiea-Chuen Khor (CC)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.

Wolfgang Koenig (W)

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.

Holly Kramer (H)

Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, USA; Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, Illinois, USA.

Bernhard K Krämer (BK)

Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Brigitte Kühnel (B)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.

Leslie A Lange (LA)

Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Wolfgang Lieb (W)

Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.

Ruth J F Loos (RJF)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Mary Ann Lukas (MA)

Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, New Mexico, USA.

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Christa Meisinger (C)

Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair of Epidemiology, Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.

Thomas Meitinger (T)

DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany.

Olle Melander (O)

Hypertension and Cardiovascular Disease, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Yuri Milaneschi (Y)

Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, the Netherlands.

Pashupati P Mishra (PP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Nina Mononen (N)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Josyf C Mychaleckyj (JC)

Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, Virginia, USA.

Girish N Nadkarni (GN)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Matthias Nauck (M)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

Kjell Nikus (K)

Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Boting Ning (B)

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Michelle L O'Donoghue (ML)

Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA; TIMI Study Group, Boston, Massachusetts, USA.

Marju Orho-Melander (M)

Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.

Sarah A Pendergrass (SA)

Geisinger Research, Biomedical and Translational Informatics Institute, Danville, Pennsylvania, USA.

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, the Netherlands.

Michael H Preuss (MH)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Services, University of Washington, Seattle, Washington, USA; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

Laura M Raffield (LM)

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.

Olli T Raitakari (OT)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Rainer Rettig (R)

Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.

Myriam Rheinberger (M)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.

Kenneth M Rice (KM)

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Alexander R Rosenkranz (AR)

Department of Internal Medicine, Division of Nephrology, Medical University Graz, Graz, Austria.

Peter Rossing (P)

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.

Charumathi Sabanayagam (C)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.

Helena Schmidt (H)

Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.

Reinhold Schmidt (R)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.

Ben Schöttker (B)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, University of Heidelberg, Heidelberg, Germany.

Christina-Alexandra Schulz (CA)

Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.

Sanaz Sedaghat (S)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Christian M Shaffer (CM)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Konstantin Strauch (K)

Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany.

Silke Szymczak (S)

Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.

Johanne Tremblay (J)

Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada; CRCHUM, Montreal, Canada; Medpharmgene, Montreal, Quebec, Canada.

Layal Chaker (L)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Pim van der Harst (P)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands.

Peter J van der Most (PJ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Niek Verweij (N)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Uwe Völker (U)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Melanie Waldenberger (M)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Lars Wallentin (L)

Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

Dawn M Waterworth (DM)

Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.

Harvey D White (HD)

Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Tien-Yin Wong (TY)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.

Mark Woodward (M)

The George Institute for Global Health, University of New South Wales, Sydney, Australia; The George Institute for Global Health, University of Oxford, Oxford, UK; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Qiong Yang (Q)

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

Masayuki Yasuda (M)

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.

Laura M Yerges-Armstrong (LM)

Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.

Yan Zhang (Y)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Christoph Wanner (C)

Division of Nephrology, University Clinic, University of Würzburg, Würzburg, Germany.

Carsten A Böger (CA)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.

Anna Köttgen (A)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Florian Kronenberg (F)

Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.

Cristian Pattaro (C)

Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.

Iris M Heid (IM)

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Electronic address: iris.heid@klinik.uni-regensburg.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Créatinine › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Sulfur-sulfur bond isomerase › Protein Disulfide-Isomerases › Meta-analysis uncovers genome-wide significant...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Meta-analysis uncovers genome-wide significant...