An actuatable soft reservoir modulates host foreign body response.

Journal

Science robotics
ISSN: 2470-9476
Titre abrégé: Sci Robot
Pays: United States
ID NLM: 101733136

Informations de publication

Date de publication:
28 Aug 2019
Historique:
received: 15 04 2019
accepted: 01 08 2019
entrez: 2 11 2020
pubmed: 28 8 2019
medline: 28 8 2019
Statut: ppublish

Résumé

The performance of indwelling medical devices that depend on an interface with soft tissue is plagued by complex, unpredictable foreign body responses. Such devices-including breast implants, biosensors, and drug delivery devices-are often subject to a collection of biological host responses, including fibrosis, which can impair device functionality. This work describes a milliscale dynamic soft reservoir (DSR) that actively modulates the biomechanics of the biotic-abiotic interface by altering strain, fluid flow, and cellular activity in the peri-implant tissue. We performed cyclical actuation of the DSR in a preclinical rodent model. Evaluation of the resulting host response showed a significant reduction in fibrous capsule thickness (

Identifiants

DOI: 10.1126/scirobotics.aax7043 PMID: 33137787
pubmed: 33137787
pii: 4/33/eaax7043
doi: 10.1126/scirobotics.aax7043
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

E B Dolan (EB)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0002-6742-8461

C E Varela (CE)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
ORCID: 0000-0001-8082-092X

K Mendez (K)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

W Whyte (W)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
Royal College of Surgeons in Ireland, Dublin, Ireland.
ORCID: 0000-0002-2458-4149

R E Levey (RE)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

S T Robinson (ST)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
Royal College of Surgeons in Ireland, Dublin, Ireland.
ORCID: 0000-0002-2911-439X

E Maye (E)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0001-6810-7670

J O'Dwyer (J)

Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

R Beatty (R)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

A Rothman (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0003-3403-1254

Y Fan (Y)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0003-1606-5071

J Hochstein (J)

Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

S E Rothenbucher (SE)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

R Wylie (R)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0002-4991-7878

J R Starr (JR)

Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.
ORCID: 0000-0002-3039-2311

M Monaghan (M)

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0002-5530-4998

P Dockery (P)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0001-5103-6589

G P Duffy (GP)

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. garry.duffy@nuigalway.ie etr@mit.edu.
Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
Royal College of Surgeons in Ireland, Dublin, Ireland.
CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
ORCID: 0000-0002-4994-9511

E T Roche (ET)

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. garry.duffy@nuigalway.ie etr@mit.edu.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0002-8952-2993

Classifications MeSH