Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression.
major depressive disorder
psychomotor symptoms
retardation
transcranial direct current stimulation
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
29 Oct 2020
29 Oct 2020
Historique:
received:
14
09
2020
revised:
19
10
2020
accepted:
25
10
2020
entrez:
3
11
2020
pubmed:
4
11
2020
medline:
4
11
2020
Statut:
epublish
Résumé
Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients. Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale-SRRS) and objective measures (kinematical analysis of movements, automatic imitation). tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results. tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.
Sections du résumé
BACKGROUND
BACKGROUND
Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients.
METHODS
METHODS
Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale-SRRS) and objective measures (kinematical analysis of movements, automatic imitation).
RESULTS
RESULTS
tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results.
CONCLUSION
CONCLUSIONS
tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.
Identifiants
pubmed: 33137986
pii: brainsci10110792
doi: 10.3390/brainsci10110792
pmc: PMC7692158
pii:
doi:
Types de publication
Journal Article
Langues
eng
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