Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Glucose
/ genetics
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ genetics
Fasting
/ blood
Female
Humans
Male
Mediterranean Region
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Pregnancy
Receptor, Melatonin, MT2
/ genetics
Retrospective Studies
Risk Assessment
Risk Factors
Spain
Young Adult
MTNR1B polymorphism
Mediterranean population
age-interaction
fasting glucose
gestational diabetes
heterogeneity
melatonin receptor
pregnancy
type-2 diabetes
women
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Oct 2020
29 Oct 2020
Historique:
received:
03
09
2020
revised:
21
10
2020
accepted:
24
10
2020
entrez:
3
11
2020
pubmed:
4
11
2020
medline:
15
4
2021
Statut:
epublish
Résumé
Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C>G variant that has been associated with fasting glucose concentrations, gestational diabetes, and type-2 diabetes. Therefore, our main aim was to investigate whether the association between the MTNR1B-rs10830963 polymorphism and fasting glucose is age dependent. Our secondary aims were to analyze the polymorphism association with type-2 diabetes and explore the gene-pregnancies interactions on the later type-2 diabetes risk. Three Mediterranean cohorts (
Identifiants
pubmed: 33138317
pii: nu12113323
doi: 10.3390/nu12113323
pmc: PMC7692445
pii:
doi:
Substances chimiques
Blood Glucose
0
MTNR1B protein, human
0
Receptor, Melatonin, MT2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : CIBER 06/03
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI06/1326
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI13/00728
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI16/00366
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : SAF2016-80532-R
Organisme : the University Jaume I
ID : P1-1B2013-54
Organisme : the University Jaume I
ID : COGRUP/2016/06
Organisme : the Rei Jaume I Award for Medical Research 2018
ID : PRJI2018
Organisme : the Fundació La Marató de TV3
ID : 538/U/2016
Organisme : the Generalitat Valenciana
ID : PROMETEO2017/017
Organisme : the Generalitat Valenciana
ID : APOSTD/2019/136
Organisme : the US Department of Agriculture, Agriculture Research Service
ID : 8050-51000-098-00D
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI19/00781
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