Allostatic Load in Cancer: A Systematic Review and Mini Meta-Analysis.
allostasis
allostatic load
cancer
neoplasm
stress
stress biomarkers
stress response
Journal
Biological research for nursing
ISSN: 1552-4175
Titre abrégé: Biol Res Nurs
Pays: United States
ID NLM: 9815758
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
pubmed:
4
11
2020
medline:
28
9
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Individuals with cancer experience stress throughout the cancer trajectory. Allostatic load (AL), a cumulative multi-system measure, may have a greater value in stress assessment and the associated biological burden than individual biomarkers. A better understanding of the use of AL and its operationalization in cancer could aid in early detection and prevention or alleviation of AL in this population. To consolidate findings on the operationalization, antecedents, and outcomes of AL in cancer. Seven databases (CINAHL, Ovid MEDLINE, Web of Science, APA PsycInfo, Scopus, Embase, and Cochrane CENTRAL) were searched for articles published through April 2020. The NIH tools were used to assess study quality. Twelve studies met inclusion criteria for this review. Although variability existed in the estimation of AL, biomarkers of cardiovascular, metabolic, and immune systems were mostly used. Associations of AL with cancer-specific variables were examined mostly utilizing population-databases. Significant associations of AL with variables such as cancer-related stress, positive cancer history, post traumatic growth, resilience, tumor pathology, and cancer-specific mortality were found. Mini meta-analysis found that a one-unit increase in AL was associated with a 9% increased risk of cancer-specific mortality. This review reveals heterogeneity in operationalization of AL in cancer research and lack of clarity regarding causal direction between AL and cancer. Nevertheless, AL holds a significant promise in cancer research and practice. AL could be included as a screening tool for high-risk individuals or a health outcome in cancer. Optimal standardized approaches to measure AL would improve its clinical utility.
Sections du résumé
BACKGROUND
Individuals with cancer experience stress throughout the cancer trajectory. Allostatic load (AL), a cumulative multi-system measure, may have a greater value in stress assessment and the associated biological burden than individual biomarkers. A better understanding of the use of AL and its operationalization in cancer could aid in early detection and prevention or alleviation of AL in this population.
PURPOSE
To consolidate findings on the operationalization, antecedents, and outcomes of AL in cancer.
METHODS
Seven databases (CINAHL, Ovid MEDLINE, Web of Science, APA PsycInfo, Scopus, Embase, and Cochrane CENTRAL) were searched for articles published through April 2020. The NIH tools were used to assess study quality.
RESULTS
Twelve studies met inclusion criteria for this review. Although variability existed in the estimation of AL, biomarkers of cardiovascular, metabolic, and immune systems were mostly used. Associations of AL with cancer-specific variables were examined mostly utilizing population-databases. Significant associations of AL with variables such as cancer-related stress, positive cancer history, post traumatic growth, resilience, tumor pathology, and cancer-specific mortality were found. Mini meta-analysis found that a one-unit increase in AL was associated with a 9% increased risk of cancer-specific mortality.
CONCLUSION
This review reveals heterogeneity in operationalization of AL in cancer research and lack of clarity regarding causal direction between AL and cancer. Nevertheless, AL holds a significant promise in cancer research and practice. AL could be included as a screening tool for high-risk individuals or a health outcome in cancer. Optimal standardized approaches to measure AL would improve its clinical utility.
Identifiants
pubmed: 33138637
doi: 10.1177/1099800420969898
pmc: PMC8755951
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
341-361Subventions
Organisme : NINR NIH HHS
ID : K24 NR015340
Pays : United States
Références
Schizophr Res. 2019 Aug;210:73-80
pubmed: 31262574
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4770-5
pubmed: 11287659
Ecancermedicalscience. 2016 Apr 05;10:631
pubmed: 27170831
J Gerontol A Biol Sci Med Sci. 2006 Oct;61(10):1070-4
pubmed: 17077201
Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):216-224
pubmed: 31719063
Psychoneuroendocrinology. 2020 May;115:104645
pubmed: 32171901
Psychoneuroendocrinology. 2018 Aug;94:134-142
pubmed: 29775876
J Palliat Med. 2019 Jul;22(7):848-857
pubmed: 30632880
Neurosci Biobehav Rev. 2010 Sep;35(1):2-16
pubmed: 19822172
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
pubmed: 19622511
Endocrinology. 2012 Sep;153(9):4120-7
pubmed: 22778226
Ann N Y Acad Sci. 2010 Feb;1186:223-39
pubmed: 20201875
Soc Sci Med. 2010 Jun;70(12):1988-1996
pubmed: 20381934
Exp Gerontol. 2005 May;40(5):438-49
pubmed: 15919596
Soc Sci Med. 2008 Feb;66(3):507-19; discussion 520-35
pubmed: 18022742
Psychother Psychosom. 2016;85(5):289-96
pubmed: 27508418
Med Sci Monit. 2019 May 14;25:3573-3582
pubmed: 31086129
Horm Behav. 2003 Jan;43(1):2-15
pubmed: 12614627
Complexity. 2016 Sep-Oct;21(Suppl 1):291-306
pubmed: 28190951
Psychother Psychosom. 2010;79(5):280-4
pubmed: 20616622
Psychother Psychosom. 2017;86(1):13-30
pubmed: 27884006
Sci Rep. 2018 Apr 23;8(1):6411
pubmed: 29686319
Stress. 2016 Nov;19(6):553-558
pubmed: 27483979
Neuropsychopharmacology. 2000 Feb;22(2):108-24
pubmed: 10649824
Afr Health Sci. 2017 Jun;17(2):428-435
pubmed: 29062338
J Am Geriatr Soc. 2009 Sep;57(9):1525-31
pubmed: 19682116
PLoS One. 2017 Aug 16;12(8):e0183297
pubmed: 28813505
Psychosom Med. 2014 Sep;76(7):478-80
pubmed: 25141272
Ethn Dis. 2020 Apr 2;30(Suppl 1):177-184
pubmed: 32269459
Lancet Psychiatry. 2017 Apr;4(4):330-338
pubmed: 28109647
Stress. 2020 Sep;23(5):519-528
pubmed: 32602798
J Sports Sci Med. 2012 Dec 01;11(4):571-81
pubmed: 24150065
Psychoneuroendocrinology. 2019 Oct;108:94-101
pubmed: 31252304
J Eval Clin Pract. 2017 Feb;23(1):199-208
pubmed: 27421249
Mol Cancer. 2019 Sep 2;18(1):132
pubmed: 31477121
Dialogues Clin Neurosci. 2006;8(4):383-95
pubmed: 17290797
Nat Rev Immunol. 2005 Mar;5(3):243-51
pubmed: 15738954
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
Biol Res Nurs. 2012 Oct;14(4):311-46
pubmed: 23007870
J Racial Ethn Health Disparities. 2017 Jun;4(3):455-461
pubmed: 27352114
Arch Intern Med. 1997 Oct 27;157(19):2259-68
pubmed: 9343003
Soc Sci Med. 2004 May;58(10):1985-97
pubmed: 15020014
Coll Antropol. 2012 Mar;36(1):11-22
pubmed: 22816193
CA Cancer J Clin. 2019 May;69(3):211-233
pubmed: 30762872
Dialogues Clin Neurosci. 2006;8(4):367-81
pubmed: 17290796
Gerontologist. 2015 Jun;55 Suppl 1:S140-5
pubmed: 26055775
Am J Public Health. 2006 May;96(5):826-33
pubmed: 16380565
JAMA Surg. 2017 May 1;152(5):485-493
pubmed: 28355428
J Am Med Dir Assoc. 2014 Jul;15(7):490-496
pubmed: 24631353
Ind Health. 2015;53(1):5-20
pubmed: 25224337
Arch Intern Med. 1993 Sep 27;153(18):2093-101
pubmed: 8379800
Psychooncology. 2013 Mar;22(3):621-8
pubmed: 22290849
J Pediatr Oncol Nurs. 2014 May-Jun;31(3):122-34
pubmed: 24647010
Psychosom Med. 2016 Apr;78(3):290-301
pubmed: 26734956
J Clin Epidemiol. 2002 Jul;55(7):696-710
pubmed: 12160918
J Natl Med Assoc. 2012 Jan-Feb;104(1-2):89-95
pubmed: 22708252
Br J Cancer. 2017 Nov 7;117(10):1486-1494
pubmed: 28926525
Am J Cardiol. 2017 Dec 15;120(12):2284-2288
pubmed: 29096885
Physiol Rev. 2007 Jul;87(3):873-904
pubmed: 17615391
Cancer. 2018 Jan 15;124(2):406-416
pubmed: 29152719
Psychoneuroendocrinology. 2012 May;37(5):589-601
pubmed: 21974976
Sci Rep. 2020 Mar 19;10(1):5047
pubmed: 32193496
Am J Hum Biol. 2014 Nov-Dec;26(6):768-76
pubmed: 25088793
Nutrients. 2019 Sep 29;11(10):
pubmed: 31569527
Int J Nephrol Renovasc Dis. 2015 Jun 01;8:53-7
pubmed: 26082658