Preoperative prognostic nutritional index predicts risk of recurrence after curative resection for stage IIA colon cancer.
Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Clinical Decision-Making
/ methods
Colectomy
Colonic Neoplasms
/ blood
Disease-Free Survival
Feasibility Studies
Female
Follow-Up Studies
Humans
Inflammation
/ blood
Lymphocyte Count
Male
Middle Aged
Neoplasm Recurrence, Local
/ epidemiology
Neoplasm Staging
Neutrophils
/ immunology
Nutrition Assessment
Platelet Count
Preoperative Period
Prognosis
Proportional Hazards Models
ROC Curve
Retrospective Studies
Risk Assessment
/ methods
Adjuvant chemotherapy
Prognostic nutritional index
Stage IIA colon Cancer
Journal
American journal of surgery
ISSN: 1879-1883
Titre abrégé: Am J Surg
Pays: United States
ID NLM: 0370473
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
28
07
2020
revised:
12
10
2020
accepted:
23
10
2020
pubmed:
4
11
2020
medline:
4
8
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery. This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR. Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005-4.317; P = 0.049) independently and significantly predicted RFS. PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
Sections du résumé
BACKGROUND
Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery.
METHODS
This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR.
RESULTS
Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005-4.317; P = 0.049) independently and significantly predicted RFS.
CONCLUSION
PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
Identifiants
pubmed: 33138968
pii: S0002-9610(20)30672-3
doi: 10.1016/j.amjsurg.2020.10.032
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-185Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.