Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia.
Animals
Cardiotonic Agents
/ pharmacology
Cell Communication
Connexins
/ metabolism
Disease Models, Animal
Drug Delivery Systems
Extracellular Vesicles
Gap Junctions
Humans
Myocardial Infarction
/ pathology
Myocardial Ischemia
/ pathology
Myocardium
/ cytology
Myocytes, Cardiac
/ metabolism
Signal Transduction
acute myocardial infarction
cardioprotection
extracellular vesicles
gap junctions
intercellular communication
remote ischemic conditioning
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
09
07
2020
revised:
04
10
2020
accepted:
07
10
2020
pubmed:
4
11
2020
medline:
30
11
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
The maintenance of tissue, organ, and organism homeostasis relies on an intricate network of players and mechanisms that assist in the different forms of cell-cell communication. Myocardial infarction, following heart ischemia and reperfusion, is associated with profound changes in key processes of intercellular communication, involving gap junctions, extracellular vesicles, and tunneling nanotubes, some of which have been implicated in communication defects associated with cardiac injury, namely arrhythmogenesis and progression into heart failure. Therefore, intercellular communication players have emerged as attractive powerful therapeutic targets aimed at preserving a fine-tuned crosstalk between the different cardiac cells in order to prevent or repair some of harmful consequences of heart ischemia and reperfusion, re-establishing myocardial function.
Identifiants
pubmed: 33139169
pii: S1471-4914(20)30263-X
doi: 10.1016/j.molmed.2020.10.002
pii:
doi:
Substances chimiques
Cardiotonic Agents
0
Connexins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-262Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.