Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 11 2020
02 11 2020
Historique:
received:
25
06
2019
accepted:
23
09
2020
entrez:
3
11
2020
pubmed:
4
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the long-term HIV-1 reservoir decay. Our findings indicate that viral genetic factors contribute to the HIV-1 reservoir size and hence the infecting HIV-1 strain may affect individual patients' hurdle towards a cure.
Identifiants
pubmed: 33139735
doi: 10.1038/s41467-020-19198-7
pii: 10.1038/s41467-020-19198-7
pmc: PMC7608612
doi:
Substances chimiques
Anti-Retroviral Agents
0
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5542Investigateurs
Alexia Anagnostopoulos
(A)
Manuel Battegay
(M)
Enos Bernasconi
(E)
Jürg Böni
(J)
Dominique L Braun
(DL)
Heiner C Bucher
(HC)
Alexandra Calmy
(A)
Matthias Cavassini
(M)
Angela Ciuffi
(A)
Günter Dollenmaier
(G)
Matthias Egger
(M)
Luigia Elzi
(L)
Jan Fehr
(J)
Jacques Fellay
(J)
Hansjakob Furrer
(H)
Christoph A Fux
(CA)
Huldrych F Günthard
(HF)
David Haerry
(D)
Barbara Hasse
(B)
Hans H Hirsch
(HH)
Matthias Hoffmann
(M)
Irene Hösli
(I)
Michael Huber
(M)
Christian Kahlert
(C)
Laurent Kaiser
(L)
Olivia Keiser
(O)
Thomas Klimkait
(T)
Roger D Kouyos
(RD)
Helen Kovari
(H)
Bruno Ledergerber
(B)
Gladys Martinetti
(G)
Begona Martinez de Tejada
(BM)
Catia Marzolini
(C)
Karin J Metzner
(KJ)
Nicolas Müller
(N)
Dunja Nicca
(D)
Paolo Paioni
(P)
Guiseppe Pantaleo
(G)
Matthieu Perreau
(M)
Andri Rauch
(A)
Christoph Rudin
(C)
Alexandra U Scherrer
(AU)
Patrick Schmid
(P)
Roberto Speck
(R)
Marcel Stöckle
(M)
Philip Tarr
(P)
Alexandra Trkola
(A)
Pietro Vernazza
(P)
Gilles Wandeler
(G)
Rainer Weber
(R)
Sabine Yerly
(S)
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