Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
09
2019
accepted:
08
09
2020
pubmed:
4
11
2020
medline:
9
1
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural Environments (PASTURE) birth cohort, we modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was associated with previous farm exposure (β = 0.27 (0.12-0.43), P = 0.001, n = 618) and reduced risk of asthma at school age (odds ratio (OR) = 0.72 (0.56-0.93), P = 0.011). EMA mediated the protective farm effect by 19%. In a nested case-control sample (n = 138), we found inverse associations of asthma with the measured level of fecal butyrate (OR = 0.28 (0.09-0.91), P = 0.034), bacterial taxa that predict butyrate production (OR = 0.38 (0.17-0.84), P = 0.017) and the relative abundance of the gene encoding butyryl-coenzyme A (CoA):acetate-CoA-transferase, a major enzyme in butyrate metabolism (OR = 0.43 (0.19-0.97), P = 0.042). The gut microbiome may contribute to asthma protection through metabolites, supporting the concept of a gut-lung axis in humans.
Identifiants
pubmed: 33139948
doi: 10.1038/s41591-020-1095-x
pii: 10.1038/s41591-020-1095-x
doi:
Substances chimiques
Butyrates
0
RNA, Ribosomal, 16S
0
Coenzyme A-Transferases
EC 2.8.3.-
butyryl-CoA acetoacetate CoA transferase
EC 2.8.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1766-1775Investigateurs
Jon Genuneit
(J)
Anne Hyvärinen
(A)
Sabina Illi
(S)
Lucie Laurent
(L)
Petra I Pfefferle
(PI)
Bianca Schaub
(B)
Erika von Mutius
(E)
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