Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth.
ER stress
hyperlipidemia
mTOR signaling
macrophage
microRNA
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
03 12 2020
03 12 2020
Historique:
received:
04
08
2020
revised:
19
09
2020
accepted:
22
09
2020
pubmed:
4
11
2020
medline:
28
4
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
The ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated by mammalian IRE1 cannot be fully explained by IRE1's one known, specific RNA target, X box-binding protein-1 (XBP1) or the RNA substrates of IRE1-dependent RNA degradation (RIDD) activity. Investigating other specific substrates of IRE1 kinase and RNase activities may illuminate how it performs these diverse functions in mammalian cells. We report that macrophage IRE1 plays an unprecedented role in regulating phosphatidylinositide-derived signaling lipid metabolites and has profound impact on the downstream signaling mediated by the mammalian target of rapamycin (mTOR). This cross-talk between UPR and mTOR pathways occurs through the unconventional maturation of microRNA (miR) 2137 by IRE1's RNase activity. Furthermore, phosphatidylinositol (3,4,5) phosphate (PI(3,4,5)P
Identifiants
pubmed: 33140520
doi: 10.15252/embr.202051462
pmc: PMC7726810
doi:
Substances chimiques
Phosphatidylinositols
0
Inositol
4L6452S749
ERN1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Endoribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e51462Subventions
Organisme : Fulbright Association (FULBRIGHT)
ID : FY-2017-TR-PD-01
Organisme : FP7 Ideas: European Research Council (FP7 Ideas)
ID : 336643
Organisme : FP7 Ideas: European Research Council (FP7 Ideas)
ID : 692511
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB 1123
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : TRR 267-A02
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : DFG Transregio 83
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : DFG Transregio 86
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors.
Références
EMBO Rep. 2020 Dec 3;21(12):e51462
pubmed: 33140520
Nat Cell Biol. 2016 Nov 29;18(12):1263-1265
pubmed: 27897158
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14343-8
pubmed: 16973740
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10519-24
pubmed: 18650380
Cell Rep. 2019 Nov 26;29(9):2702-2717.e7
pubmed: 31775039
J Mol Cell Biol. 2016 Apr;8(2):144-56
pubmed: 26711306
Mol Cell. 2011 Sep 16;43(6):892-903
pubmed: 21925378
Metabolism. 2016 Sep;65(9):1238-46
pubmed: 27506731
Life Sci. 2019 Aug 15;231:116569
pubmed: 31202841
Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22
pubmed: 19143635
Elife. 2016 Dec 10;5:
pubmed: 27938665
PLoS One. 2010 Sep 14;5(9):e12732
pubmed: 20856872
Sci Rep. 2012;2:799
pubmed: 23150771
Nature. 2001 Jan 18;409(6818):363-6
pubmed: 11201747
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404
pubmed: 28137856
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4628-33
pubmed: 23487760
Curr Neuropharmacol. 2018;16(9):1340-1347
pubmed: 29663887
Circ Res. 2019 Jan 4;124(1):79-93
pubmed: 30582446
Cell. 1993 May 7;73(3):585-96
pubmed: 8387896
Anim Biotechnol. 2018 Apr 3;29(2):110-118
pubmed: 28636491
Endocrinology. 2008 Feb;149(2):642-50
pubmed: 18039790
Curr Protoc Immunol. 2008 Nov;Chapter 14:Unit 14.1
pubmed: 19016445
Cell. 2010 Mar 19;140(6):900-17
pubmed: 20303879
J Cell Sci. 2016 Mar 15;129(6):1101-14
pubmed: 26826186
Nat Cell Biol. 2019 Jun;21(6):755-767
pubmed: 31110288
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1881-9
pubmed: 26976605
Annu Rev Nutr. 2017 Aug 21;37:423-446
pubmed: 28645222
J Endocrinol. 2008 Jun;197(3):553-63
pubmed: 18492819
Nat Rev Immunol. 2013 Oct;13(10):709-21
pubmed: 23995626
J Biol Chem. 2012 Apr 6;287(15):11629-41
pubmed: 22356914
Science. 2012 Nov 9;338(6108):818-22
pubmed: 23042294
Nature. 2018 Dec;564(7734):71-76
pubmed: 30487600
Nucleic Acids Res. 2008 Jan;36(Database issue):D149-53
pubmed: 18158296
Nat Cell Biol. 2011 Mar;13(3):184-90
pubmed: 21364565
Chem Phys Lipids. 2014 May;180:23-43
pubmed: 24418527
Nature. 2010 Jun 3;465(7298):584-9
pubmed: 20424607
Sci Signal. 2018 May 15;11(530):
pubmed: 29764990
BMC Biol. 2011 Jul 06;9:47
pubmed: 21729333
Mol Cell Biol. 2003 Nov;23(21):7448-59
pubmed: 14559994
Sci Rep. 2016 Dec 01;6:36758
pubmed: 27905554
Sci Transl Med. 2016 Sep 28;8(358):358ra126
pubmed: 27683551
Nat Rev Immunol. 2008 Dec;8(12):923-34
pubmed: 19029988
PLoS One. 2013 Nov 20;8(11):e79805
pubmed: 24278182
Nat Med. 2004 Jan;10(1):98-102
pubmed: 14702639
Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429
pubmed: 31371506
Nat Med. 2009 Dec;15(12):1383-91
pubmed: 19966778
Adv Enzyme Regul. 2003;43:15-28
pubmed: 12791379
Biosci Rep. 2019 May 14;39(5):
pubmed: 30992393
Curr Opin Cell Biol. 2015 Apr;33:67-73
pubmed: 25543896
Hepatology. 2011 Aug;54(2):452-62
pubmed: 21488074
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
pubmed: 19805353
Mol Cell. 2017 Aug 17;67(4):673-684.e8
pubmed: 28689662
Cell Metab. 2010 Jan;11(1):47-57
pubmed: 20074527
J Biol Chem. 1998 Jun 5;273(23):14484-94
pubmed: 9603962
J Cell Biol. 2010 May 31;189(5):783-94
pubmed: 20513765
Physiology (Bethesda). 2009 Aug;24:231-44
pubmed: 19675354
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
Sci Rep. 2017 Nov 28;7(1):16497
pubmed: 29184100
Circulation. 2018 Oct 30;138(18):2007-2020
pubmed: 29748186
J Nutr. 2010 May;140(5):879-84
pubmed: 20237065
J Immunol. 2017 Dec 1;199(11):3858-3869
pubmed: 29061766
Trends Cell Biol. 2012 May;22(5):274-82
pubmed: 22444729
Cell Res. 2010 Jul;20(7):748-62
pubmed: 20548331
Cell Calcium. 2017 May;63:29-32
pubmed: 28262262
J Biol Chem. 2007 Nov 23;282(47):34525-34
pubmed: 17890727
Biochim Biophys Acta. 2012 Aug;1821(8):1133-45
pubmed: 22269166
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):513-522
pubmed: 28189644
J Cell Biol. 2011 Mar 21;192(6):919-27
pubmed: 21402790
Arterioscler Thromb Vasc Biol. 2012 May;32(5):1104-15
pubmed: 22383700
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Bioinformatics. 2012 Mar 15;28(6):771-6
pubmed: 22285563
J Biol Chem. 2008 Jun 27;283(26):17954-61
pubmed: 18375386
Nature. 2005 Aug 4;436(7051):740-4
pubmed: 15973356
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19300-5
pubmed: 19033458
Cell. 2007 Jun 29;129(7):1261-74
pubmed: 17604717
FEMS Yeast Res. 2010 Dec;10(8):1035-45
pubmed: 20738405
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35
pubmed: 21157483
Dev Cell. 2011 Nov 15;21(5):813-24
pubmed: 22075145
Genetics. 2002 Sep;162(1):29-43
pubmed: 12242221
J Clin Invest. 2006 Jun;116(6):1494-505
pubmed: 16691291
J Am Coll Cardiol. 2019 Mar 19;73(10):1149-1169
pubmed: 30871699
Nat Rev Mol Cell Biol. 2014 Mar;15(3):155-62
pubmed: 24556838
Curr Opin Cell Biol. 2017 Apr;45:72-82
pubmed: 28411448
Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E275-81
pubmed: 16492686
Am J Physiol Cell Physiol. 2013 Jun 15;304(12):C1117-26
pubmed: 23515532
J Lipid Res. 2011 Feb;52(2):299-307
pubmed: 21078775
J Cell Biol. 2009 Nov 16;187(4):525-36
pubmed: 19948500
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Mol Biol Cell. 2015 Aug 15;26(16):2873-84
pubmed: 26108623
J Clin Invest. 2004 Dec;114(11):1564-76
pubmed: 15578089
Genome Biol. 2010;11(8):R90
pubmed: 20799968
J Biol Chem. 2000 Oct 6;275(40):30749-52
pubmed: 10934217
J Cell Biol. 2016 Oct 10;215(1):15-25
pubmed: 27738003
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W169-73
pubmed: 23680784
Elife. 2018 Dec 24;7:
pubmed: 30582518
Cell. 2006 Feb 10;124(3):471-84
pubmed: 16469695