Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling.

Copper / chemistry HeLa Cells Humans Isotope Labeling Ligands Mass Spectrometry Metalloporphyrins / adverse effects Optical Imaging Photochemotherapy Photosensitizing Agents / adverse effects Platinum / adverse effects Structure-Activity Relationship Tissue Distribution Zinc Isotopes / chemistry

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
19 Nov 2020
Historique:
pubmed: 4 11 2020
medline: 26 5 2021
entrez: 3 11 2020
Statut: ppublish

Résumé

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.

Identifiants

DOI: 10.1039/d0cc05196a PMID: 33140750
pubmed: 33140750
doi: 10.1039/d0cc05196a
doi:

Substances chimiques

Ligands 0
Metalloporphyrins 0
Photosensitizing Agents 0
Zinc Isotopes 0
Zinc-67 0
Platinum 49DFR088MY
Copper 789U1901C5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14373-14376

Auteurs

Riccardo Rubbiani (R)

Department of Chemistry, University of Zurich, Zurich CH 8057, Switzerland. spingler@chem.uzh.ch.

Wenyu Wu (W)

Anu Naik (A)

Michele Larocca (M)

Lukas Schneider (L)

Roxane Padrutt (R)

Vipin Babu (V)

Christiane König (C)

Doris Hinger (D)

Caroline Maake (C)

Stefano Ferrari (S)

Gilles Gasser (G)

Bernhard Spingler (B)

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Studying the cellular distribution of highly...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Studying the cellular distribution of highly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Studying the cellular distribution of highly...
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › Studying the cellular distribution of highly...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Studying the cellular distribution of highly...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Studying the cellular distribution of highly...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Studying the cellular distribution of highly...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Studying the cellular distribution of highly...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Studying the cellular distribution of highly...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Studying the cellular distribution of highly...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Platine › Studying the cellular distribution of highly...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Studying the cellular distribution of highly...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Studying the cellular distribution of highly...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Isotopes du zinc › Studying the cellular distribution of highly...