Ecological level analysis of primary lung tumors in dogs and cats and environmental radon activity.
canine
epidemiology
feline
incidence
pulmonary neoplasia
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
23
12
2019
revised:
27
09
2020
accepted:
01
10
2020
pubmed:
4
11
2020
medline:
29
6
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Epidemiologic studies suggest residential radon exposure might increase the risk of primary lung cancer in people, but these studies are limited by subject mobility. This limitation might be overcome by evaluating the association in pets. Primary pulmonary neoplasia (PPN) rate is higher in dogs and cats residing in counties with a high radon exposure risk (Environmental Protection Agency [EPA] zone 1) compared to zones 2 (moderate radon exposure risk) and 3 (low radon exposure risk). Six hundred ninety client-owned dogs and 205 client-owned cats with PPN. Retrospective review of medical records at 10 veterinary colleges identified dogs and cats diagnosed with PPN between 2010 and 2015. Each patient's radon exposure was determined by matching the patient's zip code with published county radon exposure risk. County level PPN rates were calculated using the average annual county cat and dog populations. The PPN counts per 100 000 dog/cat years at risk (PPN rates) were compared across radon zones for each species. The PPN rate ratio in counties in high radon zone (1) was approximately 2-fold higher than in counties in lower radon zones for dogs (rate ratio zone 1 to 2, 2.49; 95% confidence interval [CI], 1.56-4.00; rate ratio zone 1 to 3, 2.29; 95% CI, 1.46-3.59) and cats (rate ratio zone 1 to 2, 2.13; 95% CI, 0.95-4.79; zone 1 to 3, 1.81; 95% CI, 0.9-3.61). Exposure to household radon might play a role in development of PPN in dogs and cats.
Sections du résumé
BACKGROUND
BACKGROUND
Epidemiologic studies suggest residential radon exposure might increase the risk of primary lung cancer in people, but these studies are limited by subject mobility. This limitation might be overcome by evaluating the association in pets.
HYPOTHESIS
OBJECTIVE
Primary pulmonary neoplasia (PPN) rate is higher in dogs and cats residing in counties with a high radon exposure risk (Environmental Protection Agency [EPA] zone 1) compared to zones 2 (moderate radon exposure risk) and 3 (low radon exposure risk).
ANIMALS
METHODS
Six hundred ninety client-owned dogs and 205 client-owned cats with PPN.
METHODS
METHODS
Retrospective review of medical records at 10 veterinary colleges identified dogs and cats diagnosed with PPN between 2010 and 2015. Each patient's radon exposure was determined by matching the patient's zip code with published county radon exposure risk. County level PPN rates were calculated using the average annual county cat and dog populations. The PPN counts per 100 000 dog/cat years at risk (PPN rates) were compared across radon zones for each species.
RESULTS
RESULTS
The PPN rate ratio in counties in high radon zone (1) was approximately 2-fold higher than in counties in lower radon zones for dogs (rate ratio zone 1 to 2, 2.49; 95% confidence interval [CI], 1.56-4.00; rate ratio zone 1 to 3, 2.29; 95% CI, 1.46-3.59) and cats (rate ratio zone 1 to 2, 2.13; 95% CI, 0.95-4.79; zone 1 to 3, 1.81; 95% CI, 0.9-3.61).
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Exposure to household radon might play a role in development of PPN in dogs and cats.
Identifiants
pubmed: 33140892
doi: 10.1111/jvim.15936
pmc: PMC7694848
doi:
Substances chimiques
Radon
Q74S4N8N1G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2660-2670Subventions
Organisme : Oncology Service at Iowa State University College of Veterinary Medicine
Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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