Perioperative pharmacokinetics and pharmacodynamics of meloxicam in emus (Dromaius novaehollandiae) of different age groups using nonlinear mixed effect modelling.
NonSteroidal Anti-Inflammatory Drugs
anaesthesia
analgesia
birds
whole blood assay
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
08
09
2020
received:
12
06
2020
accepted:
07
10
2020
pubmed:
4
11
2020
medline:
25
11
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Meloxicam is a widely used nonsteroidal anti-inflammatory drug in avian species. However, variability in pharmacokinetic (PK) and pharmacodynamic (PD) parameters in birds warrants species-specific studies for dose and dosing interval optimization. We performed a perioperative PK study of meloxicam (0.5 mg/kg, intravenously) on emus of three different age groups: 3 chicks (5 weeks old, 3.5 kg), 4 juveniles (26 weeks old, 18.8 kg) and 6 adults (66 weeks old, 38.8 kg). A two-compartment population PK model including weight as a significant covariate on clearance and central volume of distribution (V1) best fitted the data. The typical values (20 kg bird) for clearance and V1 were 0.54 L/kg/h and 0.095 L/kg. Both parameters significantly decreased with increasing weight/age. Meloxicam potency and selectivity for COX-1 and COX-2 were measured in whole blood assays (TxB
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cyclooxygenase 2
EC 1.14.99.1
Meloxicam
VG2QF83CGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
603-618Informations de copyright
© 2020 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.
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