Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer.
Biomarkers, Tumor
/ analysis
Breast Neoplasms
/ enzymology
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Lactoylglutathione Lyase
/ analysis
Lysine
/ analogs & derivatives
NF-E2-Related Factor 2
/ genetics
NF-kappa B
/ genetics
Neoplasm Recurrence, Local
Oxidative Stress
Progression-Free Survival
Receptor for Advanced Glycation End Products
/ genetics
Receptor, ErbB-2
/ analysis
Time Factors
Vascular Endothelial Growth Factor A
/ analysis
Advanced glycation end products
Breast cancer
Glyoxalase
Survival analysis
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
08
2020
accepted:
09
10
2020
pubmed:
4
11
2020
medline:
29
9
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Glyoxalase-1 (GLO-1) is the key enzyme in aldehyde defence in cancer cells. We here evaluated the prognostic impact and association with clinico-pathological parameters and relapse-free as well as overall survival in tumor samples from 187 breast cancer patients. The determined GLO1-immunoreactive score (GLO1-IRS) did not correlate with parameters such as grading, size, hormone receptors or ki67. However, an association of GLO1-IRS with the advanced glycation end product N
Identifiants
pubmed: 33142109
pii: S0344-0338(20)32112-9
doi: 10.1016/j.prp.2020.153257
pii:
doi:
Substances chimiques
AGER protein, human
0
Biomarkers, Tumor
0
NF-E2-Related Factor 2
0
NF-kappa B
0
NFE2L2 protein, human
0
Receptor for Advanced Glycation End Products
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
N(6)-carboxymethyllysine
70YDX3Z2O7
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
GLO1 protein, human
EC 4.4.1.5
Lactoylglutathione Lyase
EC 4.4.1.5
Lysine
K3Z4F929H6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153257Informations de copyright
Copyright © 2020 Elsevier GmbH. All rights reserved.