Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Diazepam
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Humans
Molecular Docking Simulation
Molecular Structure
Protein Kinase Inhibitors
/ chemical synthesis
Structure-Activity Relationship
Sulfonamides
/ chemistry
Vascular Endothelial Growth Factor Receptor-2
/ antagonists & inhibitors
Anticancer agents
Benzodiazepines
Molecular docking
Sulfonamide
VEGFR-2 inhibitors
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
19
07
2020
revised:
10
09
2020
accepted:
03
10
2020
pubmed:
5
11
2020
medline:
31
3
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
Novel series of diazepam bearing sulfonamide moieties 5
Identifiants
pubmed: 33142416
pii: S0045-2068(20)31648-5
doi: 10.1016/j.bioorg.2020.104350
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Protein Kinase Inhibitors
0
Sulfonamides
0
KDR protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Diazepam
Q3JTX2Q7TU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104350Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.