Obesity and Pancreatic Cancer: A Matched-Pair Survival Analysis.
morbidity
mortality
obesity
pancreatic ductal adenocarcinoma
survival
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 Oct 2020
31 Oct 2020
Historique:
received:
01
10
2020
revised:
20
10
2020
accepted:
28
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
5
11
2020
Statut:
epublish
Résumé
Morbid obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the impact of obesity on postoperative outcomes and overall survival in patients with PDAC remains a controversial topic. Patients who underwent pancreatic surgery for PDAC between 1997 and 2018 were included in this study. Matched pairs (1:1) were generated according to age, gender and American Society of Anesthesiologists status. Obesity was defined according to the WHO definition as BMI ≥ 30 kg/m Out of 553 patients, a total of 76 fully matched pairs were generated. Obese patients had a mean BMI-level of 33 compared to 25 kg/m Obesity did not affect overall survival and postoperative complications in these patients with PDAC. Therefore, pancreatic surgery should not be withheld from obese patients.
Sections du résumé
BACKGROUND
BACKGROUND
Morbid obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the impact of obesity on postoperative outcomes and overall survival in patients with PDAC remains a controversial topic.
METHODS
METHODS
Patients who underwent pancreatic surgery for PDAC between 1997 and 2018 were included in this study. Matched pairs (1:1) were generated according to age, gender and American Society of Anesthesiologists status. Obesity was defined according to the WHO definition as BMI ≥ 30 kg/m
RESULTS
RESULTS
Out of 553 patients, a total of 76 fully matched pairs were generated. Obese patients had a mean BMI-level of 33 compared to 25 kg/m
CONCLUSIONS
CONCLUSIONS
Obesity did not affect overall survival and postoperative complications in these patients with PDAC. Therefore, pancreatic surgery should not be withheld from obese patients.
Identifiants
pubmed: 33142763
pii: jcm9113526
doi: 10.3390/jcm9113526
pmc: PMC7693315
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Ther Clin Risk Manag. 2019 Oct 01;15:1141-1152
pubmed: 31632041
J Am Coll Surg. 2009 Feb;208(2):210-7
pubmed: 19228532
J Surg Res. 2011 Oct;170(2):220-5
pubmed: 21514600
Cancer Discov. 2016 Aug;6(8):852-69
pubmed: 27246539
Ann Surg. 2003 Jan;237(1):74-85
pubmed: 12496533
Ann Surg. 2004 Aug;240(2):205-13
pubmed: 15273542
J Clin Oncol. 2013 Nov 20;31(33):4229-34
pubmed: 24145341
HPB (Oxford). 2019 Aug;21(8):972-980
pubmed: 30591305
Chirurg. 2017 Dec;88(12):1040-1045
pubmed: 28660327
Br J Surg. 2016 Nov;103(12):1683-1694
pubmed: 27686238
J Gastrointest Surg. 2010 Jul;14(7):1143-50
pubmed: 20431978
Ann Oncol. 2012 Apr;23(4):843-52
pubmed: 21890910
World J Gastrointest Pathophysiol. 2013 May 15;4(2):37-42
pubmed: 23755369
Obes Surg. 2020 May;30(5):1820-1826
pubmed: 31950317
Lancet. 2004 Jan 10;363(9403):157-63
pubmed: 14726171
Ann N Y Acad Sci. 2014 Apr;1311:57-76
pubmed: 24725147
J Hepatobiliary Pancreat Sci. 2010 Mar;17(2):174-9
pubmed: 19517055
BMC Cancer. 2014 Sep 29;14:728
pubmed: 25266049
Eur J Surg Oncol. 2018 Jul;44(7):969-974
pubmed: 29784507
J Gastrointest Surg. 2008 Feb;12(2):270-8
pubmed: 18060467
Cells. 2019 Jul 03;8(7):
pubmed: 31277269
Nature. 2006 Dec 14;444(7121):875-80
pubmed: 17167476
Surgery. 2017 Mar;161(3):584-591
pubmed: 28040257
Asian J Surg. 2020 Aug;43(8):799-809
pubmed: 31732412
Arch Surg. 2009 Mar;144(3):216-21
pubmed: 19289659
Pancreas. 2011 Aug;40(6):931-7
pubmed: 21747317
World J Surg. 2003 Mar;27(3):324-9
pubmed: 12607060
J Cancer Res Clin Oncol. 2001;127(3):193-9
pubmed: 11260865
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Ann Surg. 2007 Dec;246(6):966-74; discussion 974-5
pubmed: 18043098
Ann Surg Oncol. 2009 Sep;16(9):2565-9
pubmed: 19557479
Surgery. 2007 Nov;142(5):761-8
pubmed: 17981197
Lancet. 2003 Jun 14;361(9374):2032-5
pubmed: 12814714
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
Ann Oncol. 2014 Aug;25(8):1650-6
pubmed: 24759568
Surgery. 2005 Jul;138(1):8-13
pubmed: 16003309
BMC Public Health. 2013 Jun 20;13:599
pubmed: 23786855
J Clin Oncol. 2016 Dec 10;34(35):4284-4294
pubmed: 27903151
J Invest Surg. 2019 Jun;32(4):314-320
pubmed: 29336625
Pancreas. 2014 Jan;43(1):47-52
pubmed: 24177141
Obes Rev. 2013 Nov;14 Suppl 2:11-20
pubmed: 24102717
Int J Cancer. 2010 Nov 15;127(10):2412-9
pubmed: 20143395
N Engl J Med. 2016 Aug 25;375(8):794-8
pubmed: 27557308
Zentralbl Chir. 2018 Apr;143(2):155-161
pubmed: 29719907
JAMA. 2009 Jun 24;301(24):2553-62
pubmed: 19549972
N Engl J Med. 2006 Aug 24;355(8):763-78
pubmed: 16926275
MMWR Morb Mortal Wkly Rep. 2006 Sep 15;55(36):985-8
pubmed: 16971886
Cancer. 2010 Nov 1;116(21):5054-62
pubmed: 20665496
Ann Surg. 2016 Dec;264(6):1082-1090
pubmed: 26978570
J Gastrointest Surg. 2009 Jul;13(7):1337-44
pubmed: 19418101
Surgery. 2007 Jul;142(1):20-5
pubmed: 17629996
Surgery. 2007 May;141(5):610-8
pubmed: 17462460
Surgery. 2010 Jul;148(1):15-23
pubmed: 20138325
J Gastrointest Surg. 2000 Nov-Dec;4(6):567-79
pubmed: 11307091
Surgery. 2016 Jun;159(6):1520-1527
pubmed: 26847803
Pancreatology. 2018 Jun;18(4):394-398
pubmed: 29716797
Am J Surg. 2012 Jun;203(6):684-90
pubmed: 22079032
World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
pubmed: 11234459
Am J Clin Nutr. 2006 Aug;84(2):289-98
pubmed: 16895874