Flakka: New Dangerous Synthetic Cathinone on the Drug Scene.
Flakka
bath salts
synthetic cathinone
α-pyrrolidinopentiophenone
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Oct 2020
31 Oct 2020
Historique:
received:
10
08
2020
revised:
28
10
2020
accepted:
28
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
19
3
2021
Statut:
epublish
Résumé
New psychoactive substances are being used as drugs and appear to be quite popular nowadays. Thanks to their specific properties, these drugs create inimitable experiences for intoxicated people. Synthetic cathinones are the most common compounds in these new drugs. Among them, α-pyrrolidopentadione (α-PVP), or "Flakka" (street name), is one of the most famous cathinone-designed drugs. Similar to other synthetic cathinone drugs, α-PVP can effectively inhibit norepinephrine and dopamine transmitters. The adverse reactions of α-PVP mainly include mania, tachycardia, and hallucinations. An increasing number of people are being admitted to emergency wards due to the consequences of their use. This work mainly summarizes the history, synthesis, pharmacology, toxicology, structure-activity relationship, metabolism, clinical process and health risks, poisoning and death, forensic toxicology, and legal status of α-PVP. We hope this review will help bring more attention to the exploration of this substance in order to raise awareness of its negative impacts on humans.
Identifiants
pubmed: 33142953
pii: ijms21218185
doi: 10.3390/ijms21218185
pmc: PMC7663692
pii:
doi:
Substances chimiques
Alkaloids
0
Central Nervous System Stimulants
0
Illicit Drugs
0
Pentanones
0
Psychotropic Drugs
0
Pyrrolidines
0
cathinone
540EI4406J
1-phenyl-2-(1-pyrrolidinyl)-1-pentanone
767K3AWA4R
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : UHK
ID : VT2019-2021
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