Sphingomyelinases and Liver Diseases.
acidic sphingomyelinase
alcoholic and nonalcoholic steatohepatitis
ceramide
hepatocellular carcinoma
neutral sphingomyelinase
sphingomyelin
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
30 10 2020
30 10 2020
Historique:
received:
02
10
2020
revised:
27
10
2020
accepted:
28
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
25
6
2021
Statut:
epublish
Résumé
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling pathways and cellular processes. Ceramide is a heterogeneous lipid entity determined by the length of the fatty acyl chain linked to its carbon backbone sphingosine, which can be generated either by de novo synthesis from serine and palmitoyl-CoA in the endoplasmic reticulum or via sphingomyelin (SM) hydrolysis by sphingomyelinases (SMases). Unlike de novo synthesis, SMase-induced SM hydrolysis represents a rapid and transient mechanism of ceramide generation in specific intracellular sites that accounts for the diverse biological effects of ceramide. Several SMases have been described at the molecular level, which exhibit different pH requirements for activity: neutral, acid or alkaline. Among the SMases, the neutral (NSMase) and acid (ASMase) are the best characterized for their contribution to signaling pathways and role in diverse pathologies, including liver diseases. As part of a Special Issue (Phospholipases: From Structure to Biological Function), the present invited review summarizes the physiological functions of NSMase and ASMase and their role in chronic and metabolic liver diseases, of which the most relevant is nonalcoholic steatohepatitis and its progression to hepatocellular carcinoma, due to the association with the obesity and type 2 diabetes epidemic. A better understanding of the regulation and role of SMases in liver pathology may offer the opportunity for novel treatments of liver diseases.
Identifiants
pubmed: 33143193
pii: biom10111497
doi: 10.3390/biom10111497
pmc: PMC7692672
pii:
doi:
Substances chimiques
Ceramides
0
Sphingolipids
0
Sphingomyelins
0
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : P50AA011999
Pays : United States
Références
Hepatology. 2007 May;45(5):1306-12
pubmed: 17464973
BMC Gastroenterol. 2014 Aug 07;14:138
pubmed: 25100243
Eur J Clin Microbiol Infect Dis. 2014 Oct;33(10):1725-32
pubmed: 24810965
Nat Cell Biol. 2010 Sep;12(9):836-41
pubmed: 20811356
Mol Cancer Ther. 2015 Jan;14(1):259-67
pubmed: 25381265
Obesity (Silver Spring). 2010 May;18(5):937-44
pubmed: 19798063
J Hepatol. 2010 Aug;53(2):372-84
pubmed: 20494470
Compr Physiol. 2013 Apr;3(2):977-1010
pubmed: 23720337
FEBS Lett. 2000 Mar 3;469(1):44-6
pubmed: 10708753
J Biol Chem. 2000 Feb 25;275(8):5710-7
pubmed: 10681556
Neurobiol Aging. 2014 Aug;35(8):1792-800
pubmed: 24650793
Adv Virol. 2012;2012:767694
pubmed: 22888349
Cell Microbiol. 2019 Nov;21(11):e13065
pubmed: 31155842
J Hepatol. 2014 Nov;61(5):1126-34
pubmed: 24946279
Biochim Biophys Acta. 1994 May 25;1226(2):138-44
pubmed: 8204660
Semin Liver Dis. 2007 Nov;27(4):367-77
pubmed: 17979073
J Biol Chem. 2008 May 16;283(20):13565-77
pubmed: 18337250
J Clin Invest. 2014 Aug;124(8):3566-78
pubmed: 24983318
J Pharmacol Exp Ther. 1990 Dec;255(3):935-41
pubmed: 2262912
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
J Biol Chem. 2002 Sep 27;277(39):36443-8
pubmed: 12118012
Cell Signal. 2008 Jun;20(6):1010-8
pubmed: 18191382
Vaccines (Basel). 2019 Aug 28;7(3):
pubmed: 31466253
Am J Surg Pathol. 2016 Sep;40(9):1232-42
pubmed: 27340749
Prog Lipid Res. 2009 Jan;48(1):62-72
pubmed: 19027789
J Med Chem. 2019 Jan 24;62(2):987-992
pubmed: 30525581
FASEB J. 2001 Apr;15(6):1068-70
pubmed: 11292670
J Hepatol. 2013 Jul;59(1):98-104
pubmed: 23485523
Nature. 2011 May 26;473(7348):528-31
pubmed: 21532591
Nat Med. 2007 Feb;13(2):164-70
pubmed: 17259995
Biochim Biophys Acta. 1968 Dec 18;164(3):575-84
pubmed: 5701698
J Biol Chem. 2001 Jun 8;276(23):20589-96
pubmed: 11279185
Toxicol Appl Pharmacol. 1988 May;93(3):378-87
pubmed: 3368917
J Clin Invest. 2001 Jul;108(1):143-51
pubmed: 11435466
FASEB J. 1996 Oct;10(12):1388-97
pubmed: 8903509
J Biol Chem. 2010 Jun 11;285(24):18528-36
pubmed: 20395294
Free Radic Biol Med. 1997;23(4):616-26
pubmed: 9215807
J Biol Chem. 2004 Apr 30;279(18):18384-91
pubmed: 14970205
Br J Cancer. 2007 Nov 19;97(10):1441-8
pubmed: 17923876
Mol Biol Cell. 2004 Oct;15(10):4500-11
pubmed: 15292453
Cell Oncol (Dordr). 2013 Apr;36(2):121-9
pubmed: 23248036
Hepatology. 2008 May;47(5):1495-503
pubmed: 18220271
J Biol Chem. 1997 Apr 11;272(15):9868-76
pubmed: 9092523
Oncogene. 2008 Oct 27;27(50):6434-51
pubmed: 18955971
Oxid Med Cell Longev. 2012;2012:205713
pubmed: 22720116
Mol Metab. 2014 May 22;3(5):544-53
pubmed: 25061559
Science. 2008 Feb 29;319(5867):1244-7
pubmed: 18309083
J Lipid Res. 2018 May;59(5):795-804
pubmed: 29567647
Gastroenterology. 2012 Apr;142(4):938-46
pubmed: 22240484
Adv Biol Regul. 2018 Dec;70:40-50
pubmed: 30455063
Nat Commun. 2012 Mar 13;3:731
pubmed: 22415822
Cell Signal. 2009 Jun;21(6):836-46
pubmed: 19385042
Orphanet J Rare Dis. 2017 Feb 23;12(1):41
pubmed: 28228103
Autophagy. 2012 May 1;8(5):849-50
pubmed: 22617442
Traffic. 2009 Apr;10(4):411-24
pubmed: 19192252
J Biol Chem. 2010 Nov 12;285(46):35706-18
pubmed: 20807762
World J Hepatol. 2018 Feb 27;10(2):246-253
pubmed: 29527260
Adv Biol Regul. 2015 Jan;57:24-41
pubmed: 25465297
Cell Metab. 2012 May 2;15(5):623-34
pubmed: 22560215
Cancer Biol Ther. 2011 Jan 15;11(2):138-49
pubmed: 21209555
FEBS J. 2018 Oct;285(20):3835-3848
pubmed: 30106227
Cell. 2011 Nov 11;147(4):728-41
pubmed: 22078875
Handb Exp Pharmacol. 2013;(216):29-54
pubmed: 23563650
EMBO J. 1996 May 15;15(10):2417-24
pubmed: 8665849
J Hepatol. 2013 Sep;59(3):621-5
pubmed: 23557871
Oncogene. 2012 Feb 23;31(8):939-53
pubmed: 21765470
Am J Pathol. 2010 Sep;177(3):1214-24
pubmed: 20651240
Sci Rep. 2014 Oct 20;4:6683
pubmed: 25327881
Curr Mol Med. 2010 Jul;10(5):454-66
pubmed: 20540705
Biochim Biophys Acta. 2016 Nov;1861(11):1767-1774
pubmed: 27570113
Handb Exp Pharmacol. 2013;(215):57-76
pubmed: 23579449
Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50
pubmed: 18216770
J Biol Chem. 2005 May 13;280(19):19196-204
pubmed: 15769735
J Biol Chem. 1998 Jul 17;273(29):18250-9
pubmed: 9660788
Annu Rev Nutr. 2008;28:273-93
pubmed: 18331185
Annu Rev Physiol. 1998;60:643-65
pubmed: 9558480
Toxicol Appl Pharmacol. 2005 Nov 15;209(1):62-73
pubmed: 15882883
J Hepatol. 2011 Apr;54(4):795-809
pubmed: 21145844
Cancer Biol Ther. 2008 Oct;7(10):1648-62
pubmed: 18787411
J Lipid Res. 2014 Aug;55(8):1609-21
pubmed: 24664998
Nat Rev Gastroenterol Hepatol. 2013 Jul;10(7):384
pubmed: 23752821
PLoS One. 2018 Dec 31;13(12):e0205886
pubmed: 30596665
Mediators Inflamm. 2015;2015:520618
pubmed: 26648664
Int J Mol Sci. 2018 Dec 13;19(12):
pubmed: 30551571
Nature. 2009 Apr 30;458(7242):1131-5
pubmed: 19339967
Mol Genet Metab. 2015 Sep-Oct;116(1-2):88-97
pubmed: 26049896
J Leukoc Biol. 2010 Nov;88(5):897-903
pubmed: 20534702
J Lipid Res. 2008 Nov;49(11):2356-64
pubmed: 18541923
PLoS One. 2017 Jun 14;12(6):e0177805
pubmed: 28614356
FASEB J. 2004 Jun;18(9):968-70
pubmed: 15059969
J Biol Chem. 2010 Apr 2;285(14):10911-23
pubmed: 20110366
Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1257-65
pubmed: 9714132
Trends Cell Biol. 2000 Feb;10(2):73-80
pubmed: 10652518
N Engl J Med. 2000 Nov 16;343(20):1467-76
pubmed: 11078773
Mol Genet Metab. 2017 Jan - Feb;120(1-2):27-33
pubmed: 28164782
Autophagy. 2013 Aug;9(8):1131-58
pubmed: 23774882
Sci Rep. 2015 Dec 11;5:18017
pubmed: 26657973
Biochem Biophys Res Commun. 2001 Jan 26;280(3):634-9
pubmed: 11162568
J Biol Chem. 2000 Mar 24;275(12):8657-63
pubmed: 10722706
Free Radic Biol Med. 2001 Jan 1;30(1):89-97
pubmed: 11134899
Nat Rev Cancer. 2004 Aug;4(8):604-16
pubmed: 15286740
Cancer Cell. 2017 Dec 11;32(6):807-823.e12
pubmed: 29232555
J Biol Chem. 2010 Apr 2;285(14):10902-10
pubmed: 20110363
Oncotarget. 2015 Apr 20;6(11):9420-33
pubmed: 25826083
J Biol Chem. 2010 Apr 2;285(14):10213-22
pubmed: 20106976
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):99-105
pubmed: 16269668
Hepatology. 2004 Jul;40(1):6-9
pubmed: 15239078
Lancet. 2010 Jul 17;376(9736):190-201
pubmed: 20638564
Mol Genet Metab. 2017 Jan - Feb;120(1-2):34-37
pubmed: 27923544
Antioxid Redox Signal. 2014 Jan 20;20(3):460-73
pubmed: 23725295
Dig Dis Sci. 1998 Jan;43(1):26-32
pubmed: 9508530
Pediatrics. 2004 Dec;114(6):e672-7
pubmed: 15545621
Cell Metab. 2010 Jun 9;11(6):467-78
pubmed: 20519119
Hepatology. 2006 Sep;44(3):561-72
pubmed: 16941686
Prog Lipid Res. 2012 Jan;51(1):50-62
pubmed: 22133871
J Biol Chem. 1996 Aug 2;271(31):18431-6
pubmed: 8702487
Hepatology. 2003 Jun;37(6):1425-34
pubmed: 12774022
Nat Genet. 1995 Jul;10(3):288-93
pubmed: 7670466
Trends Cell Biol. 2008 Apr;18(4):157-64
pubmed: 18314333
J Biol Chem. 2004 Jun 11;279(24):25101-11
pubmed: 15051724
J Inherit Metab Dis. 2005;28(2):203-27
pubmed: 15877209
J Lipid Res. 2002 Feb;43(2):316-24
pubmed: 11861674
Med Sci Monit. 2015 May 29;21:1562-8
pubmed: 26031757
J Biol Chem. 2013 Apr 12;288(15):10849-59
pubmed: 23439645
EMBO J. 2009 Apr 22;28(8):1043-54
pubmed: 19300439
EMBO J. 2001 Jun 1;20(11):2690-701
pubmed: 11387204
Biochem J. 1993 Mar 15;290 ( Pt 3):751-7
pubmed: 8457204
Mol Cell. 2010 Oct 22;40(2):267-79
pubmed: 20965421
Biochim Biophys Acta. 1986 May 21;876(3):526-32
pubmed: 3011102
Apoptosis. 2006 Jul;11(7):1149-59
pubmed: 16699952
Biochim Biophys Acta. 2007 Feb;1771(2):196-201
pubmed: 17204455
J Cell Sci. 2016 Sep 1;129(17):3262-73
pubmed: 27422101
Rev Med Interne. 2017 May;38(5):291-299
pubmed: 27884455
FEBS J. 2015 May;282(10):1858-70
pubmed: 25735653
J Biol Chem. 1994 Feb 4;269(5):3125-8
pubmed: 8106344
Gastroenterology. 1994 Dec;107(6):1788-98
pubmed: 7958693
J Clin Invest. 2003 Jan;111(2):197-208
pubmed: 12531875
Gastroenterology. 2003 Dec;125(6):1868-77
pubmed: 14724838
PLoS One. 2013 May 28;8(5):e65620
pubmed: 23724146
Mol Genet Metab. 2016 Jul;118(3):206-13
pubmed: 27198631
Hoppe Seylers Z Physiol Chem. 1976 Sep;357(9):1321-31
pubmed: 992582
Future Oncol. 2010 Oct;6(10):1603-24
pubmed: 21062159
Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191
pubmed: 29165427
Front Physiol. 2017 Nov 30;8:982
pubmed: 29249985
Redox Rep. 2017 Jul;22(4):147-159
pubmed: 27077455
Eur Biophys J. 1998;27(4):361-6
pubmed: 9691465
Free Radic Res. 2017 Mar;51(3):253-268
pubmed: 28277984
J Inherit Metab Dis. 2018 Sep;41(5):829-838
pubmed: 29305734
J Hepatol. 2013 Oct;59(4):805-13
pubmed: 23707365
J Lipid Res. 2009 Apr;50 Suppl:S91-6
pubmed: 19017611
Semin Liver Dis. 2013 Nov;33(4):321-9
pubmed: 24222090
J Lipid Res. 2003 Jun;44(6):1241-50
pubmed: 12671034
J Biol Chem. 2000 Sep 8;275(36):28316-25
pubmed: 10871611
BMC Cancer. 2014 May 09;14:327
pubmed: 24885292
Cell. 1994 May 6;77(3):325-8
pubmed: 8181053
Biochim Biophys Acta. 2006 Mar;1761(3):281-91
pubmed: 16631405
J Biol Chem. 2012 Jan 6;287(2):1178-88
pubmed: 22102288
Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G515-23
pubmed: 22194417
Handb Clin Neurol. 2013;113:1717-21
pubmed: 23622394
Brain. 1948 Dec;71(Pt. 4):410-5
pubmed: 18124738
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5895-900
pubmed: 10823942
Alcohol Clin Exp Res. 2000 Oct;24(10):1557-65
pubmed: 11045865
Hepatology. 2004 Nov;40(5):1170-9
pubmed: 15486922
Toxicol Sci. 2006 Jan;89(1):31-41
pubmed: 16177235
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3638-43
pubmed: 9520418
Pediatrics. 2008 Aug;122(2):e341-9
pubmed: 18625664
J Clin Invest. 2004 Mar;113(6):895-904
pubmed: 15067322
Front Immunol. 2015 May 04;6:203
pubmed: 25999947
J Biol Chem. 1997 Apr 25;272(17):11369-77
pubmed: 9111045
Hepatol Res. 2015 Mar;45(3):305-14
pubmed: 24796378
BMB Rep. 2017 Mar;50(3):144-149
pubmed: 28193314
Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283
pubmed: 28275693
Cell Metab. 2012 May 2;15(5):585-94
pubmed: 22560211
J Hepatol. 2011 Dec;55(6):1353-60
pubmed: 21803012
Neurology. 2006 Jan 24;66(2):228-32
pubmed: 16434659
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2659-65
pubmed: 15308476
Oncotarget. 2016 Feb 16;7(7):8253-67
pubmed: 26811497
Mol Genet Metab. 2020 May;130(1):16-26
pubmed: 32088119
Hepatology. 2019 Nov;70(5):1600-1613
pubmed: 31062368
Nat Commun. 2016 Jul 20;7:12196
pubmed: 27435900
Nat Med. 2013 Jul;19(7):934-8
pubmed: 23770692
Biochim Biophys Acta. 2014 Jul;1841(7):1012-20
pubmed: 24769340
J Biol Chem. 2010 Jun 4;285(23):17993-8002
pubmed: 20378533