Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Oct 2020
Historique:
received: 03 10 2020
revised: 21 10 2020
accepted: 28 10 2020
entrez: 4 11 2020
pubmed: 5 11 2020
medline: 27 3 2021
Statut: epublish

Résumé

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO

Identifiants

pubmed: 33143240
pii: ijms21218131
doi: 10.3390/ijms21218131
pmc: PMC7662373
pii:
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Hypoxia-Inducible Factor 1 0
endothelial PAS domain-containing protein 1 1B37H0967P

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : CRC/Transregio 205/1, Project No. 314061271 - TRR205, "The Adrenal: Central Relay in Health and Disease"
Organisme : Deutsche Forschungsgemeinschaft
ID : WI3291/5-1 and 12-1
Organisme : Deutsche Forschungsgemeinschaft
ID : µBONE 2084

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Auteurs

Deepika Watts (D)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Diana Gaete (D)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Diego Rodriguez (D)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

David Hoogewijs (D)

Section of Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, 1700 Fribourg, Switzerland.

Martina Rauner (M)

Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, 01307 Dresden, Germany.

Sundary Sormendi (S)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Ben Wielockx (B)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

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Classifications MeSH