Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.
Antiviral Agents
/ therapeutic use
Carcinoma, Hepatocellular
/ drug therapy
Genome-Wide Association Study
Hepacivirus
/ genetics
Hepatitis C
/ complications
Hepatitis C, Chronic
/ drug therapy
Humans
Japan
/ epidemiology
Liver Cirrhosis
/ drug therapy
Liver Neoplasms
/ drug therapy
Polymorphism, Single Nucleotide
BioBank Japan
GWAS
HCV
SNP
TGFBI
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
30
06
2020
revised:
16
07
2020
accepted:
17
07
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach. We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project. We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls. Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach.
MATERIALS AND METHODS
METHODS
We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project.
RESULTS
RESULTS
We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls.
CONCLUSION
CONCLUSIONS
Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted.
Identifiants
pubmed: 33144438
pii: 34/6/3309
doi: 10.21873/invivo.12169
pmc: PMC7811607
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3309-3313Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Références
PLoS One. 2017 Feb 8;12(2):e0171185
pubmed: 28178326
Clin Gastroenterol Hepatol. 2019 Jun;17(7):1356-1363
pubmed: 30529733
Hepatol Int. 2012 Apr;6(2):409-35
pubmed: 26201405
J Virol. 2017 Feb 28;91(6):
pubmed: 28077652
Hepatology. 2009 Mar;49(3):960-8
pubmed: 19085953
Int J Dev Biol. 2008;52(5-6):781-90
pubmed: 18649290
PLoS One. 2013 Dec 11;8(12):e81312
pubmed: 24349054
J Epidemiol. 2017 Mar;27(3S):S43-S48
pubmed: 28214185
Anticancer Res. 2019 Apr;39(4):2217-2226
pubmed: 30952770
Nat Genet. 2009 Oct;41(10):1105-9
pubmed: 19749757
Nature. 2003 Dec 18;426(6968):789-96
pubmed: 14685227
Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):122-132
pubmed: 27924080
Gastroenterology. 2006 May;130(6):1679-87
pubmed: 16697732
Cancer. 2016 Jun 1;122(11):1757-65
pubmed: 26998818
Nat Genet. 2011 Jul 03;43(8):797-800
pubmed: 21725309
J Hepatol. 1997 Oct;27(4):677-87
pubmed: 9365044
Mol Syst Biol. 2019 Mar 1;15(3):e8793
pubmed: 30824564
Mol Biosyst. 2014 May;10(5):1117-25
pubmed: 24599568
J Epidemiol. 2017 Mar;27(3S):S2-S8
pubmed: 28189464
Hepatology. 1995 Mar;21(3):650-5
pubmed: 7875662
Hepatology. 1997 Sep;26(3 Suppl 1):21S-28S
pubmed: 9305659
Hepatol Res. 2019 Sep;49(9):990-1002
pubmed: 31364248
Gastroenterology. 2018 Jun;154(8):2111-2121.e8
pubmed: 29535028
Discov Med. 2016 Aug;22(119):29-42
pubmed: 27585228
PLoS One. 2015 Apr 24;10(4):e0123311
pubmed: 25909381