Effect of the intake of dietary protein on insulin resistance in subjects with obesity: a randomized controlled clinical trial.

Adolescent Body Mass Index Diet, Reducing Dietary Proteins Humans Insulin Resistance Obesity Weight Loss

Branched-chain amino acids Dietary protein Insulin resistance Obesity Weight loss

Journal

European journal of nutrition

ISSN: 1436-6215

Titre abrégé: Eur J Nutr

Pays: Germany

ID NLM: 100888704

Informations de publication

Date de publication:
Aug 2021

Historique:

received: 18 06 2020

accepted: 19 10 2020

pubmed: 5 11 2020

medline: 15 7 2021

entrez: 4 11 2020

Statut: ppublish

Résumé

We compared the effect of diets with different amounts and sources of dietary protein on insulin sensitivity (IS) in subjects with obesity and insulin resistance (IR). Eighty subjects with obesity (BMI ≥ 30 kg/m Body weight, BMI and waist circumference decreased in all groups. Interestingly, the IS improved more in the Animal HP (Matsuda index; 1.39 vs 2.58, P = 0.003) and in the Vegetable HP groups (Matsuda index; 1.44 vs 3.14, P < 0.0001) after one month. The fat mass, triglyceride levels, C-reactive protein levels and the leptin/adiponectin index decreased; while, the skeletal muscle mass increased in the Animal and Vegetable HP groups. The BP decreased in all groups except the Animal NP group. Our study demonstrates that a high-protein hypocaloric diets improves IS by 60-90% after one month in subjects with obesity and IR, regardless of weight loss and the source of protein, either animal or vegetable. The trial is registered at clinicaltrials.gov (NCT03627104), August 13, 2018.

Identifiants

DOI: 10.1007/s00394-020-02428-5 PMID: 33145643

pubmed: 33145643

doi: 10.1007/s00394-020-02428-5

pii: 10.1007/s00394-020-02428-5

doi:

Substances chimiques

Dietary Proteins 0

Banques de données

ClinicalTrials.gov

['NCT03627104']

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

Pagination

2435-2447

Subventions

Organisme : Consejo Nacional de Ciencia y Tecnología

ID : PN-2016-01-3324

Organisme : Consejo Nacional de Ciencia y Tecnología

ID : Scholarship

Informations de copyright

Références

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