The oxysterol receptor GPR183 in inflammatory bowel diseases.
EBI2
GPR183
Ubac2
colitis
inflammatory bowel diseases
innate lymphoid cells
oxysterols
solitary intestinal lymphoid tissue
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
29
09
2020
received:
29
06
2020
accepted:
12
10
2020
pubmed:
5
11
2020
medline:
22
9
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory bowel disease (IBD). The oxysterol receptor GPR183 and its ligands, dihydroxylated oxysterols, can mediate positioning of immune cells including innate lymphoid cells. GPR183 has been mapped to an IBD risk locus, however another gene, Ubac2 is encoded on the reverse strand and associated with Behçet's disease, therefore the role of GPR183 as a genetic risk factor requires validation. GPR183 and production of its oxysterol ligands are up-regulated in human IBD and murine colitis. Gpr183 inactivation reduced severity of colitis in group 3 innate lymphoid cells-dependent colitis and in IL-10 colitis but not in dextran sodium sulphate colitis. Irrespectively, Gpr183 knockout strongly reduced accumulation of intestinal lymphoid tissue in health and all colitis models. In conclusion, genetic, translational and experimental studies implicate GPR183 in IBD pathogenesis and GPR183-dependent cell migration might be a therapeutic drug target for IBD. LINKED ARTICLES: This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc.
Substances chimiques
GPR183 protein, human
0
Gpr183 protein, mouse
0
Receptors, G-Protein-Coupled
0
Receptors, Steroid
0
oxysterol binding protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3140-3156Informations de copyright
© 2020 The British Pharmacological Society.
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