Evolutionary history of ATP-binding cassette proteins.
ABC transporters
ATP-binding cassette proteins
phylogenetics
protein evolution
sequence variation
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
21
07
2020
revised:
01
10
2020
accepted:
15
10
2020
pubmed:
5
11
2020
medline:
5
6
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
ATP-binding cassette (ABC) proteins are found in every sequenced genome and evolved deep in the phylogenetic tree of life. ABC proteins form one of the largest homologous protein families, with most being involved in substrate transport across biological membranes, and a few cytoplasmic members regulating in essential processes like translation. The predominant ABC protein classification scheme is derived from human members, but the increasing number of fully sequenced genomes permits to reevaluate this paradigm in the light of the evolutionary history the ABC-protein superfamily. As we study the diversity of substrates, mechanisms, and physiological roles of ABC proteins, knowledge of the evolutionary relationships highlights similarities and differences that can be attributed to specific branches in protein divergence. While alignments and trees built on natural sequence variation account for the evolutionary divergence of ABC proteins, high-throughput experiments and next-generation sequencing creating experimental sequence variation are instrumental in identifying functional constraints. The combination of natural and experimentally produced sequence variation allows a broader and more rational study of the function and physiological roles of ABC proteins.
Identifiants
pubmed: 33145769
doi: 10.1002/1873-3468.13985
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Nucleotides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3882-3897Informations de copyright
© 2020 Federation of European Biochemical Societies.
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