Extracellular vesicle-associated organotropic metastasis.
cancer
exosomes
extracellular vesicles
metastasis
microvesicles
organotropism
Journal
Cell proliferation
ISSN: 1365-2184
Titre abrégé: Cell Prolif
Pays: England
ID NLM: 9105195
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
18
08
2020
revised:
28
09
2020
accepted:
14
10
2020
pubmed:
5
11
2020
medline:
20
1
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
Metastasis refers to the progressive dissemination of primary tumour cells and their colonization of other tissues and is associated with most cancer-related mortalities. The disproportional and systematic distribution pattern of distant metastasis in different cancers has been well documented, as is termed metastatic organotropism, a process orchestrated by a combination of anatomical, pathophysiological, genetic and biochemical factors. Extracellular vesicles (EVs), nanosized cell-derived membrane-bound particles known to mediate intercellular communication, are now considered crucial in organ-specific metastasis. Here, we review and summarize recent findings regarding EV-associated organotropic metastasis as well as some of the general mechanisms by which EVs contribute to this important process in cancer and provide a future perspective on this emerging topic. We highlight studies that demonstrate a role of tumour-derived EVs in organotropic metastasis via pre-metastatic niche modulation. The bioactive cargo carried by EVs is of diagnostic and prognostic values, and counteracting the functions of such EVs may be a novel therapeutic strategy targeting metastasis. Further investigations are warranted to better understand the functions and mechanisms of EVs in organotropic metastasis and accelerate the relevant clinical translation.
Identifiants
pubmed: 33145869
doi: 10.1111/cpr.12948
pmc: PMC7791170
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12948Subventions
Organisme : National University of Singapore
ID : R-184-000-295-733
Organisme : City University of Hong Kong Jockey Club College of Veterinary Medicine and Life Sciences
Informations de copyright
© 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.
Références
Trends Mol Med. 2011 Jul;17(7):347-62
pubmed: 21481637
Sci Rep. 2017 May 16;7(1):1991
pubmed: 28512335
Nano Lett. 2019 May 8;19(5):2993-3001
pubmed: 30964695
Elife. 2019 May 30;8:
pubmed: 31144616
Nat Commun. 2019 Mar 27;10(1):1387
pubmed: 30918259
J Lipid Res. 2018 Oct;59(10):1793-1804
pubmed: 29678957
J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):169-80
pubmed: 16025223
Front Mol Neurosci. 2017 Aug 31;10:276
pubmed: 28912682
Nat Commun. 2019 Dec 2;10(1):5476
pubmed: 31792209
J Cell Sci. 2019 Jul 1;132(13):
pubmed: 31263077
ACS Appl Mater Interfaces. 2020 Jan 29;12(4):5136-5146
pubmed: 31894690
J Natl Cancer Inst. 2015 May 13;107(7):
pubmed: 25972604
Trends Cancer. 2015 Sep;1(1):76-91
pubmed: 28741564
Cancer Metastasis Rev. 2016 Dec;35(4):669-676
pubmed: 27838868
Exp Mol Med. 2019 Mar 15;51(3):1-12
pubmed: 30872574
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
Lancet Oncol. 2006 Nov;7(11):925-34
pubmed: 17081918
J Extracell Vesicles. 2019 Apr 14;8(1):1599680
pubmed: 31044053
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
ACS Nano. 2019 Dec 24;13(12):13853-13865
pubmed: 31479239
Sci Adv. 2020 Mar 11;6(11):eaaz6162
pubmed: 32195353
Carcinogenesis. 2018 Dec 13;39(11):1368-1379
pubmed: 30184100
Nature. 2015 Nov 5;527(7576):100-104
pubmed: 26479035
Hepatology. 2018 Aug;68(2):723-750
pubmed: 29624699
Mol Ther. 2017 Jan 4;25(1):181-191
pubmed: 28129113
Adv Exp Med Biol. 2019;1152:105-129
pubmed: 31456182
Nat Rev Cancer. 2016 Apr;16(4):201-18
pubmed: 27009393
Cells. 2018 Aug 01;7(8):
pubmed: 30071693
Diabetologia. 2019 Dec;62(12):2179-2187
pubmed: 31690986
Stem Cells. 2017 Apr;35(4):851-858
pubmed: 28294454
Int J Biol Sci. 2020 Jan 1;16(4):620-632
pubmed: 32025210
Gene. 2018 Aug 5;666:116-122
pubmed: 29730429
Nat Rev Clin Oncol. 2018 Oct;15(10):617-638
pubmed: 29795272
Dev Cell. 2019 May 6;49(3):375-391
pubmed: 31063756
Cancer Res. 2018 Aug 1;78(15):4316-4330
pubmed: 30026327
Liver Int. 2006 Dec;26(10):1175-86
pubmed: 17105582
J Extracell Vesicles. 2013 Jun 18;2:
pubmed: 24009892
J Clin Invest. 2016 Apr 1;126(4):1224-32
pubmed: 27035813
Surg Clin North Am. 2010 Aug;90(4):643-53
pubmed: 20637938
Int J Cancer. 2005 Feb 20;113(5):752-60
pubmed: 15499615
Nat Rev Cancer. 2005 Jan;5(1):21-8
pubmed: 15630412
Am J Respir Crit Care Med. 2015 Oct 1;192(7):799-809
pubmed: 26131844
Cancer Res. 2010 Dec 1;70(23):9621-30
pubmed: 21098712
Cell Adh Migr. 2015;9(5):345-56
pubmed: 26312653
J Extracell Vesicles. 2017 Sep 3;6(1):1369805
pubmed: 28959386
Cell Mol Life Sci. 2017 Feb;74(4):697-713
pubmed: 27582126
J Cell Biochem. 2018 Jun;119(6):4711-4716
pubmed: 29278659
Circ Res. 2018 Jan 19;122(2):197-198
pubmed: 29348245
Nat Commun. 2018 Dec 19;9(1):5395
pubmed: 30568162
PLoS One. 2014 Apr 16;9(4):e95240
pubmed: 24740415
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
Connect Tissue Res. 2018 Mar;59(2):99-107
pubmed: 28324674
Cancer Metastasis Rev. 1989 Aug;8(2):98-101
pubmed: 2673568
J Extracell Vesicles. 2018 Mar 13;7(1):1446660
pubmed: 29696074
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
J Biol Chem. 2014 Feb 14;289(7):3869-75
pubmed: 24398677
Nat Rev Urol. 2020 Jan;17(1):11-27
pubmed: 31827264
Cancer Cell. 2014 Apr 14;25(4):501-15
pubmed: 24735924
Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C1-C14
pubmed: 27076614
Cancer Cell. 2016 Aug 8;30(2):243-256
pubmed: 27505671
Mol Cell Proteomics. 2014 Dec;13(12):3558-71
pubmed: 25271300
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Oncogene. 2019 Mar;38(10):1751-1763
pubmed: 30353168
Clin Chim Acta. 2016 Feb 15;454:28-32
pubmed: 26724367
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
Neuro Oncol. 2020 Jul 7;22(7):967-978
pubmed: 32080744
Nat Commun. 2020 Mar 5;11(1):1211
pubmed: 32139701
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
N Engl J Med. 2019 Dec 19;381(25):2416-2428
pubmed: 31851799
J Clin Invest. 2016 Apr 1;126(4):1139-43
pubmed: 27035805
Nat Commun. 2017 Apr 10;8:15016
pubmed: 28393839
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2204-2209
pubmed: 29440427
Clin Cancer Res. 2007 Dec 1;13(23):7003-11
pubmed: 18056176
Mol Cancer. 2019 Dec 3;18(1):175
pubmed: 31796058
Mol Cell Proteomics. 2012 Aug;11(8):230-43
pubmed: 22345510
Nat Commun. 2014 Apr 07;5:3591
pubmed: 24710016
N Engl J Med. 2020 May 14;382(20):1894-1905
pubmed: 32402160
Nat Cell Biol. 2019 Feb;21(2):190-202
pubmed: 30598531
Br J Cancer. 2019 Jul;121(1):5-14
pubmed: 31110329
Nat Commun. 2017 Feb 16;8:14450
pubmed: 28205552
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7022-7027
pubmed: 29915060
Cancer Res. 2016 Dec 1;76(23):6816-6827
pubmed: 27760789
Br J Cancer. 2020 Mar;122(6):801-811
pubmed: 31937922
Cancer Cell. 2019 Jan 14;35(1):33-45.e6
pubmed: 30645975
Vaccine. 2008 Jul 4;26(29-30):3662-72
pubmed: 18538453
Front Immunol. 2018 Jul 03;9:1534
pubmed: 30018618
Cancer Cell. 2016 Dec 12;30(6):836-848
pubmed: 27960084
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24012-24018
pubmed: 31732668
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
Oncotarget. 2016 Dec 27;7(52):86999-87015
pubmed: 27894104
J Cell Sci. 2010 May 15;123(Pt 10):1603-11
pubmed: 20445011
Mol Ther. 2017 Jul 5;25(7):1665-1675
pubmed: 28284981
Commun Biol. 2019 Oct 18;2:386
pubmed: 31646189
Nat Biomed Eng. 2017;1:
pubmed: 28791195
Nat Cell Biol. 2019 Nov;21(11):1403-1412
pubmed: 31685984
Nat Med. 2012 Jun;18(6):883-91
pubmed: 22635005
J Virol. 2018 Oct 12;92(21):
pubmed: 30111566
Nature. 2015 Jul 9;523(7559):177-82
pubmed: 26106858
Clin Cancer Res. 2018 Jan 1;24(1):181-188
pubmed: 29051321
Elife. 2016 Feb 27;5:e10250
pubmed: 26920219
Nat Commun. 2015 Apr 01;6:6716
pubmed: 25828099
Mol Cancer. 2018 Mar 20;17(1):74
pubmed: 29558959
Cancer Sci. 2016 Apr;107(4):385-90
pubmed: 26797692
Comp Hepatol. 2002 Aug 23;1(1):1
pubmed: 12437787
Theranostics. 2019 Oct 17;9(26):8001-8017
pubmed: 31754377
Trends Mol Med. 2019 May;25(5):382-394
pubmed: 30853173
Nat Rev Immunol. 2019 Nov;19(11):660-661
pubmed: 31591534
Exp Mol Med. 2020 Jan;52(1):1-6
pubmed: 31915368
Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794
pubmed: 30061414
Sci Transl Med. 2019 May 15;11(492):
pubmed: 31092696
Cancer Metastasis Rev. 2008 Mar;27(1):41-55
pubmed: 18071636
Circ Res. 2017 May 12;120(10):1649-1657
pubmed: 28495995
Clin Cancer Res. 2017 Jul 15;23(14):3721-3733
pubmed: 28053020
Br J Cancer. 2012 Feb 14;106(4):768-74
pubmed: 22240788
N Engl J Med. 2018 Sep 06;379(10):958-966
pubmed: 30184457
Mol Cancer Res. 2016 Nov;14(11):1136-1146
pubmed: 27439335
Cell Prolif. 2021 Jan;54(1):e12948
pubmed: 33145869
Sci Rep. 2018 May 29;8(1):8267
pubmed: 29844613
Nat Cell Biol. 2015 Jun;17(6):816-26
pubmed: 25985394