Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases.
TENT5
TUT4/7
polyadenylation
terminal nucleotidyltransferase
uridylation
Journal
Wiley interdisciplinary reviews. RNA
ISSN: 1757-7012
Titre abrégé: Wiley Interdiscip Rev RNA
Pays: United States
ID NLM: 101536955
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
17
04
2020
revised:
25
06
2020
accepted:
26
06
2020
pubmed:
5
11
2020
medline:
15
12
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
Termini often determine the fate of RNA molecules. In recent years, 3' ends of almost all classes of RNA species have been shown to acquire nontemplated nucleotides that are added by terminal nucleotidyltransferases (TENTs). The best-described role of 3' tailing is the bulk polyadenylation of messenger RNAs in the cell nucleus that is catalyzed by canonical poly(A) polymerases (PAPs). However, many other enzymes that add adenosines, uridines, or even more complex combinations of nucleotides have recently been described. This review focuses on metazoan TENTs, which are either noncanonical PAPs or terminal uridylyltransferases with varying processivity. These enzymes regulate RNA stability and RNA functions and are crucial in early development, gamete production, and somatic tissues. TENTs regulate gene expression at the posttranscriptional level, participate in the maturation of many transcripts, and protect cells against viral invasion and the transposition of repetitive sequences. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Processing > 3' End Processing RNA Turnover and Surveillance > Regulation of RNA Stability.
Identifiants
pubmed: 33145994
doi: 10.1002/wrna.1622
pmc: PMC7988573
doi:
Substances chimiques
RNA, Messenger
0
RNA
63231-63-0
Nucleotidyltransferases
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1622Informations de copyright
© 2020 The Authors. WIREs RNA published by Wiley Periodicals LLC.
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