Computational Design of BH3-Mimetic Peptide Inhibitors That Can Bind Specifically to Mcl-1 or Bcl-X
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
17 11 2020
17 11 2020
Historique:
pubmed:
5
11
2020
medline:
30
3
2021
entrez:
4
11
2020
Statut:
ppublish
Résumé
Interactions between pro- and anti-apoptotic Bcl-2 proteins decide the fate of the cell. The BH3 domain of pro-apoptotic Bcl-2 proteins interacts with the exposed hydrophobic groove of their anti-apoptotic counterparts. Through their design and development, BH3 mimetics that target the hydrophobic groove of specific anti-apoptotic Bcl-2 proteins have the potential to become anticancer drugs. We have developed a novel computational method for designing sequences with BH3 domain features that can bind specifically to anti-apoptotic Mcl-1 or Bcl-X
Identifiants
pubmed: 33146015
doi: 10.1021/acs.biochem.0c00661
doi:
Substances chimiques
Myeloid Cell Leukemia Sequence 1 Protein
0
Peptidomimetics
0
bcl-X Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4379-4394Subventions
Organisme : Wellcome Trust/DBT India Alliance
ID : IA/I(S)/12/2/500635