Macrophage Immune Memory Controls Endometriosis in Mice and Humans.
IL-10
LPS
bacterial infections
endometriosis
fibrosis
immunology
inflammation
macrophages
mice
trained immunity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
received:
07
01
2020
revised:
22
07
2020
accepted:
07
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
8
5
2021
Statut:
ppublish
Résumé
Endometriosis is a frequent, chronic, inflammatory gynecological disease characterized by the presence of ectopic endometrial tissue causing pain and infertility. Macrophages have a central role in lesion establishment and maintenance by driving chronic inflammation and tissue remodeling. Macrophages can be reprogrammed to acquire memory-like characteristics after antigenic challenge to reinforce or inhibit a subsequent immune response, a phenomenon termed "trained immunity." Here, whereas bacille Calmette-Guérin (BCG) training enhances the lesion growth in a mice model of endometriosis, tolerization with repeated low doses of lipopolysaccharide (LPS
Identifiants
pubmed: 33147452
pii: S2211-1247(20)31314-0
doi: 10.1016/j.celrep.2020.108325
pii:
doi:
Substances chimiques
Cytokines
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108325Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.