Comparison of Haploidentical Bone Marrow versus Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide in Patients with Acute Leukemia.
Adolescent
Adult
Aged
Bone Marrow Transplantation
/ adverse effects
Cyclophosphamide
/ administration & dosage
Female
Follow-Up Studies
Graft vs Host Disease
/ epidemiology
Histocompatibility Testing
Humans
Incidence
Leukemia, Myeloid, Acute
/ immunology
Male
Middle Aged
Myeloablative Agonists
/ administration & dosage
Peripheral Blood Stem Cell Transplantation
/ adverse effects
Retrospective Studies
Transplantation Conditioning
/ methods
Transplantation, Haploidentical
Treatment Outcome
Unrelated Donors
Young Adult
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
21
07
2020
revised:
31
08
2020
accepted:
30
10
2020
pubmed:
6
11
2020
medline:
19
1
2022
entrez:
5
11
2020
Statut:
ppublish
Résumé
Posttransplant cyclophosphamide (PTCy) is increasingly being utilized as a principle GvHD prophylaxis strategy in allogeneic hematopoietic cell transplantation (allo-HCT). A haploidentical (haplo) or matched unrelated donor (UD) is a valid option in the absence of a matched related donor. We compared the outcomes of patients with acute leukemia who underwent haplo bone marrow (haplo-BM, The median follow-up duration was 36 months in the haplo-BM group and 16.6 months in the UD-PB group, respectively ( The use of a haplo donor with a BM graft resulted in a lower incidence of GvHD compared with a UD-PB stem cell graft in the setting of PTCy for patients with acute leukemia. However, differences in GvHD did not translate into a difference in survival outcomes. Based upon these data, UD-PB or haplo-BM should be considered equally acceptable sources for allo-HCT.
Identifiants
pubmed: 33148668
pii: 1078-0432.CCR-20-2809
doi: 10.1158/1078-0432.CCR-20-2809
doi:
Substances chimiques
Myeloablative Agonists
0
Cyclophosphamide
8N3DW7272P
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
843-851Informations de copyright
©2020 American Association for Cancer Research.
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