Effect of Nonsurgical Periodontal Therapy on Serum Levels of Interleukin-1β and Interleukin-8 in Smokers and Nonsmokers with Chronic Periodontitis.
Chronic periodontitis
interleukin
scaling and root planing
smoking
Journal
Journal of pharmacy & bioallied sciences
ISSN: 0976-4879
Titre abrégé: J Pharm Bioallied Sci
Pays: India
ID NLM: 101537209
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
31
01
2020
revised:
05
02
2020
accepted:
09
03
2020
entrez:
5
11
2020
pubmed:
6
11
2020
medline:
6
11
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on serum levels of interleukin-1β (IL-1β) and interleukin-8 (IL-8) in smokers and nonsmokers with chronic periodontitis before and after scaling and root planing (SRP). This was a comparative interventional study including a total of 52 (26 smokers and 26 nonsmokers with chronic periodontitis) subjects. Clinical parameters (gingival index [GI], plaque index [PI], recession, probing pocket depth [PPD], and clinical attachment level [CAL]) were recorded at baseline and 4 weeks after initial periodontal therapy. Initial periodontal therapy included oral hygiene instructions and full mouth SRP. Venous blood sample of 5 mL was collected from each subject at baseline and 4 weeks after initial periodontal therapy to evaluate serum IL-1β and IL-8. These biochemical parameters were assayed using enzyme-linked immunosorbent assay (ELISA) method. The periodontal parameters such as PI, GI, recession, PPD, and CAL were reduced after nonsurgical periodontal therapy. Smokers with chronic periodontitis showed statistically significant lower GI and higher PI, gingival recession, PPD, and CAL as compared to nonsmokers with chronic periodontitis. Statistically significant reduction in periodontal parameters was seen in both groups after periodontal therapy. IL-1β and IL-8 were increased in both groups at baseline; after SRP both groups showed statistically significant reduction in IL-1β and smokers with chronic periodontitis showed statistically significant increase in IL-8 after SRP. Smokers with chronic periodontitis showed more periodontal destruction and systemic inflammatory markers compared to nonsmokers with chronic periodontitis. After periodontal therapy both groups showed statistically significant improvement in clinical parameters and biochemical parameters excluding IL-8.
Identifiants
pubmed: 33149478
doi: 10.4103/jpbs.JPBS_93_20
pii: JPBS-12-313
pmc: PMC7595457
doi:
Types de publication
Journal Article
Langues
eng
Pagination
S313-S318Informations de copyright
Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Periodontol 2000. 2005;37:124-37
pubmed: 15655029
Immunol Ser. 1992;57:387-416
pubmed: 1504142
Acta Odontol Scand. 2001 Jun;59(3):154-60
pubmed: 11501884
J Clin Periodontol. 2000 Apr;27(4):250-5
pubmed: 10783838
J Clin Periodontol. 2005 Feb;32(2):200-6
pubmed: 15691352
Blood. 1996 Mar 15;87(6):2095-147
pubmed: 8630372
J Clin Periodontol. 2002 Feb;29(2):123-8
pubmed: 11895539
Periodontol 2000. 1997 Jun;14:9-11
pubmed: 9567963
J Periodontol. 2007 Jan;78(1):104-11
pubmed: 17199546
Int J Dent. 2012;2012:362905
pubmed: 22114600
J Periodontol. 1967 Nov-Dec;38(6):Suppl:610-6
pubmed: 5237684
J Am Dent Assoc. 2009 Mar;140(3):294-306
pubmed: 19255173
Acta Odontol Scand. 1963 Dec;21:533-51
pubmed: 14121956
J Periodontol. 2000 Jan;71(1):73-8
pubmed: 10695941
Oral Surg Oral Med Oral Pathol. 1981 Dec;52(6):577-82
pubmed: 6947180
J Clin Periodontol. 1996 Nov;23(11):982-8
pubmed: 8951624
J Clin Periodontol. 1995 Oct;22(10):743-9
pubmed: 8682920
Ann Periodontol. 1999 Dec;4(1):1-6
pubmed: 10863370
J Clin Periodontol. 2003 Jan;30(1):42-8
pubmed: 12702110