Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI.

MRI Multiple sclerosis cerebellum ultra-high field MRI

Journal

Multiple sclerosis journal - experimental, translational and clinical
ISSN: 2055-2173
Titre abrégé: Mult Scler J Exp Transl Clin
Pays: United States
ID NLM: 101668877

Informations de publication

Date de publication:
Historique:
received: 01 05 2020
revised: 21 08 2020
accepted: 04 09 2020
entrez: 5 11 2020
pubmed: 6 11 2020
medline: 6 11 2020
Statut: epublish

Résumé

To date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS. The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those changes on clinical performance. Eighteen RRMS patients and nine healthy controls underwent quantitative T The volume of the cerebellar cortex and its layers did not differ between patients and controls. In MS patients, significantly longer T We found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes. This microstructural alteration appears to be related to EDSS and cognitive performance.

Sections du résumé

BACKGROUND BACKGROUND
To date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS.
OBJECTIVE OBJECTIVE
The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those changes on clinical performance.
METHODS METHODS
Eighteen RRMS patients and nine healthy controls underwent quantitative T
RESULTS RESULTS
The volume of the cerebellar cortex and its layers did not differ between patients and controls. In MS patients, significantly longer T
CONCLUSIONS CONCLUSIONS
We found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes. This microstructural alteration appears to be related to EDSS and cognitive performance.

Identifiants

DOI: 10.1177/2055217320961409 PMID: 33149930 PMC: PMC7586276
pubmed: 33149930
doi: 10.1177/2055217320961409
pii: 10.1177_2055217320961409
pmc: PMC7586276
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2055217320961409

Informations de copyright

© The Author(s) 2020.

Déclaration de conflit d'intérêts

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Riccardo Galbusera reports no disclosures in relationship to this work Katrin Parmar reports no disclosures in relationship to this work Yohan Boillat reports no disclosures in relationship to this work Mario Joao Fartaria works for Siemens Switzerland Alexandra-Ramona Todea reports no disclosures in relationship to this work Kieran O’Brien works for Siemens Australia Anna Smolinski reports no disclosures in relationship to this work Ludwig Kappos reports no disclosures in relationship to this work Wietske van der Zwaag reports no disclosures in relationship to this work Cristina Granziera reports no disclosures in relationship to this work.

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Auteurs

Riccardo Galbusera (R)

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
ORCID: 0000-0002-3092-8737

Katrin Parmar (K)

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Yohan Boillat (Y)

Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Mario Joao Fartaria (MJ)

Advanced Clinical Imaging Technology, Siemens Healthcare AG (HC CMEA SUI DI BM PI), Lausanne, Switzerland.

Alexandra-Ramona Todea (AR)

Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Kieran O' Brien (KO)

Siemens Healthcare Pty Ltd., Bowen Hills, Australia; Centre for Advanced Imaging, University of Queensland, Australia.

Anna Smolinski (A)

Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Ludwig Kappos (L)

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
ORCID: 0000-0003-4175-5509

Wietske van der Zwaag (W)

Spinoza Centre for Neuroimaging, Amsterdam, Netherlands.

Cristina Granziera (C)

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Classifications MeSH